Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity.

In conclusion, rodent models of NAFLD alter MCLR toxicokinetics and acute toxicity and may have implications for liver and kidney pathologies in NAFLD patients. PMID: 30849452 [PubMed - as supplied by publisher]
Source: Toxicon - Category: Toxicology Authors: Tags: Toxicon Source Type: research

Related Links:

ConclusionsA clinically relevant model of PTA of venous stenosis in mice was created. PTA-treated vessels had increased lumen vessel area and WSS. The alterations in tissue markers of vascular remodeling, tissue hypoxia, proliferation, and cell death may be implications for future design of drug and device development.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Conclusions: The results indicated that probiotic food and supplement withLactobacillus andBifidobacterium could be used as interventions to improve specific anthropometric and biochemical outcomes among individuals withMetS. However, probiotic treatment alone could not reduce overall health risks. In addition, there were methodological drawbacks among reviewed studies, and further research is needed.Ann Nutr Metab 2019;74:224 –241
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
Abstract: Preeclampsia is a complication of pregnancy that affects approximately 4% of pregnancies. Preeclampsia is defined as new-onset hypertension after 20 weeks gestation often accompanied by new-onset proteinuria. Women who experience preeclampsia during pregnancy are at an increased risk for hypertension and stroke later in life. Healthcare providers should screen women appropriately to minimize risk.
Source: The Nurse Practitioner - Category: Nursing Tags: Feature: WOMEN'S HEALTH: DNP SPECIAL ISSUE Source Type: research
BEST supplements for cholesterol: Having high cholesterol can pose a huge risk to a person ’s health, so what can you do to lower it? Eating an unhealthy diet is one of the main causes of the condition, but some research has shown certain vitamins, minerals and natural substances can lower high cholesterol levels.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Behavioral variant frontotemporal dementia (bvFTD) is characterized by severe changes in personality/behavior. Recent studies have provided evidence that a decrease in serotonin receptors and neuronal loss in the raphe nuclei play a role in the bvFTD pathology. Serotonergic antidepressants have been reported to diminish behavioral disturbances in bvFTD, particularly repetitive behaviors, disinhibition, apathy, sexually inappropriate behaviors, and hyperorality. Here, we present the case of an 80-year-old Caucasian male patient with clinically and biomarker supported bvFTD ( “probable” bvFTD; disease-specific al...
Source: Case Reports in Neurology - Category: Neurology Source Type: research
Authors: Szuster-Ciesielska A, Zwolak A, Daniluk J, Kandefer-Szerszeń M Abstract Fatty liver is characterized by excessive accumulation of triglycerides within hepatocytes. Recent findings indicate that natural history of nonalcoholic fatty liver is regulated, in part, by endogenous cannabinoids. Metformin is an oral hypoglycemic medication which inhibits gluconeogenesis and glycogenolysis in hepatocytes and limits lipid storage in the liver through the inhibition of free fatty acid formation via induction of activated protein kinase activity (AMPK). Both endocannabinoids and metformin may modulate hepatosteatosis...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
ConclusionsWe demonstrate that overexpression of Lcn2 in adipose tissue not only preserves adipose tissue function during aging but also promotes maintenance of glucose tolerance, decreases dyslipidemia, and prevents liver lipid accumulation and steatosis.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Developmental exposure to stress hormones, glucocorticoids, is central to the process of prenatal programming of later life health. Glucocorticoid overexposure, through stress or exogenous glucocorticoids, results in reduced birthweight, as well as affective and neuropsychiatric outcomes in adults, combined with altered hypothalamus-pituitary-adrenal (HPA) axis activity. As such, glucocorticoids are tightly regulated during development through the presence of the metabolising enzyme 11 β-Hydroxysteroid Dehydrogenase type 2 (HSD2). HSD2 is highly expressed in two hubs during development: the placenta and the fetus itse...
Source: Neuroendocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 19 March 2019Source: Journal of EthnopharmacologyAuthor(s): Ochuko L. Erukainure, Olajumoke A. Oyebode, Omamuyovwi M. Ijomone, Chika I. Chukwuma, Neil A. Koorbanally, Md. Shahidul IslamAbstractEthnopharmacological relevanceRaffia palm (Raphia hookeri) wine (RPW) is amongst the natural products from plants, utilized singly or in combination with other medicinal plants for the treatment of several ailments including Diabetes Mellitus (DM). However, there is a scientific dearth on its antidiabetic activity.AimThe antidiabetic effect of RPW and its possible mechanism of actions were investiga...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsSMI helps maintain the proper assembly of the TJ multiprotein complex in lipid rafts, thereby helping to preserve BBB functional integrity during focal cerebral ischemic insult. Our findings enhance our understanding of the mechanisms underlying the neuroprotective effect of SMI in cerebral ischemia.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
More News: Cholesterol | Chronic Kidney Disease | Diets | Fatty Liver Disease (FLD) | High Fat | Liver | Liver Disease | Non-alcoholic Fatty Liver Diseases (NAFLD) | Nutrition | Organic | Pathology | Proteinuria | Study | Toxicology | Urology & Nephrology