Factors affecting KRAS mutation detection in colorectal cancer tissue.
CONCLUSIONS: The biopsy specimens showed better sample DNA quality for KRAS mutation test compared to resection specimens. In a routine diagnostic pathology setting, the cold ischemia time was an important factor affecting DNA quality and the formalin fixation had a wide time range for optimal DNA quality.
PMID: 30846412 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - Category: Pathology Authors: Yun HG, Lee HJ, Kim BR, Lee JH, Lee JH, Lee MY, Kim DH, Sohn JH, Chae SW, Do IG, Do SI, Kim K Tags: Pathol Res Pract Source Type: research