Pea-like Nanocabins enable autonomous cruise and step-by-step drug pushing for deep tumor inhibition

Publication date: Available online 8 March 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Ming Wu, Jiaojiao Chen, Hanitrarimalala Veroniaina, Subhankar Mukhopadhyay, Ziheng Wu, Zhenghong Wu, Xiaole QiAbstractPea-like nanocabins (HA@APT§DOX) were designed for deeply tumor inhibition. The AS1411 aptamer (APT) constituted “core shelf” which guaranteed DOX “beans” could be embedded, while the outer HA acted as “pea shell” coating. During the circulation (primary orbit), HA@APT§DOX could autonomously cruise until leak through tumor vasculature. Upon tumor superficial site, the “pea shell” could be degraded by high expressed hyaluronic acid enzymes (HAase) and peel-off, resulting in orbit changing of released APT§DOX to reach the deep tumor tissue. Furthermore, APT§DOX could be specifically uptaken into A549 tumor cells (secondary orbit). Finally, DOX was released under the acidic environment of lysosome, and delivered into nuclear (targeting orbit) to achieve drug pushing for deep tumor inhibition. More importantly, the in vivo imaging and anti-tumor effects evaluations showed that these nanocabins could effectively enhance drugs accumulation in tumor sites and inhibit tumor growth, with reduced systemic toxicity in 4 T1 tumor-bearing mice.Graphical AbstractPea-like nanocabins (HA@APT§DOX) were designed for deeply tumor inhibition. The APT constituted “core shelf” which guaranteed DOX “beans” could be embedded, while the outer...

Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 9, 2019 Category: Nanotechnology Source Type: research