Working memory training integrates visual cortex into beta-band networks in congenitally blind individuals

Publication date: Available online 7 March 2019Source: NeuroImageAuthor(s): Johanna M. Rimmele, Helene Gudi-Mindermann, Guido Nolte, Brigitte Röder, Andreas K. EngelAbstractCongenitally blind individuals have been shown to activate the visual cortex during non-visual tasks. The neuronal mechanisms of such cross-modal activation are not fully understood. Here, we used an auditory working memory training paradigm in congenitally blind and in sighted adults. We hypothesized that the visual cortex gets integrated into auditory working memory networks, after these networks have been challenged by training. The spectral profile of functional networks was investigated which mediate cross-modal reorganization following visual deprivation. A training induced integration of visual cortex into task-related networks in congenitally blind individuals was expected to result in changes in long-range functional connectivity in the theta-, beta- and gamma band (imaginary coherency) between visual cortex and working memory networks. Magnetoencephalographic data were recorded in congenitally blind and sighted individuals during resting state as well as during a voice-based working memory task; the task was performed before and after working memory training with either auditory or tactile stimuli, or a control condition. Auditory working memory training strengthened theta-band (2.5–5 Hz) connectivity in the sighted and beta-band (17.5–22.5 Hz) connectivity in the blind. In sighted parti...

Source: NeuroImage - March 9, 2019 Category: Neuroscience Source Type: research