The 'London Patient' goes into HIV remission: Here's what that means

The 'London Patient' saw his HIV go into remission after receiving a bone marrow transplant in which the blood had a mutation that did not allow HIV to multiply.
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news

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Floyd Rohan Not only do racial and ethnic minority children and adolescents with chronic illness experience disparities in health status and health outcomes, they also experience significant healthcare disparities, including differences in healthcare coverage, access to care, and quality of care. It is well known that the interaction between psychosocial functioning, health behaviors and ethnic and racial disparities, ultimately leads to worse health and psychosocial outcomes in pediatric and AYA chronic illness patient populations, including increased rates of morbidity and mortality. Investigating the impact of ra...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Commentary Source Type: research
The American Society for Transplantation and Cellular Therapy position statement on MMR prevention in immunocompromised cancer and hematopoietic cell transplantation (HCT) patients by Pergam et. al. addresses many of the concerns both providers and patients have about Measles prevention post-transplant.1 However, we are skeptical about the data regarding the safety of the MMR vaccination guidelines for post-allogenic bone marrow transplant patients as stated in this article.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Innovation in the cancer treatment space offers great promise, but even when approved by the European Medicines Agency (EMA) and other national regulatory bodies, patients can still face protracted delays in accessing new treatments.    Uncertainties in the evidence base for pioneering therapies can lead to delays from health technology assessment (HTA) agencies and payers in securing reimbursement.    To accelerate progress here, HTA frameworks must evolve, says Clare Hague, Therapy Area Market Access Lead, Hematology at Janssen EMEA, speaking ahead of the upcoming eyeforpharma Barcelona 2020 confere...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
Conclusion Despite multimodality therapy, high risk neuroblastoma had a propensity of treatment failure in terms of relapsed or refractory, with some objective responses after 131I-mIBG treatments. The declined or non-rising Curie score upon second post-treatment total body scan was an important predictor of survival and aided a decision whether or not to proceed with bone marrow transplantation.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
In this study, we developed three novel strategies of microglia replacement with high replacement efficiency: microglia replacement by bone marrow transplantation (Mr BMT), microglia replacement by peripheral blood (Mr PB) and microglia replacement by microglia transplantation (Mr MT). Mr BMT and Mr PB allow allogeneic microglia-like cells to efficiently replace the resident microglia (up to 98%) at the brain-wide scale. In contrast, Mr MT achieves local replacement of allogeneic microglia in regions of interest. Each approach has its own advantages and application scenarios. We thus believe that the novel microglia replac...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Publication date: Available online 12 March 2020Source: Hematology/Oncology and Stem Cell TherapyAuthor(s): Dilan A. Patel, Adeseye M. Akinsete, Josu de la Fuente, Adetola A. Kassim
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
Researchers reveal Adam Castillejo still in remission 12 months after ‘cure’ declaredThe patient who became the second person ever to be cleared of HIV remains free of the virus a year after initial reports of a “cure”, researchers have revealed.Adam Castillejo, who wasuntil Monday known only as the “London patient”,wasdeclared free of HIV last year, 18 months after stopping antiretroviral therapy following a stem cell, or bone marrow, transplant to treat a type of blood cancer.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Aids and HIV Medical research Science London UK news Health Society Source Type: news
Adam Castillejo, 40, was known only as the 'London patient' until today. He was anonymised by doctors who revealed he had been cured of HIV after having a bone marrow transplant for blood cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Abstract There is accumulating evidence that aging shifts the central nervous system milieu towards a proinflammatory state, with increased reactivity of microglia in the aging eye and brain having been implicated in the development of age-related neurodegenerative conditions. Indeed, alterations to microglial morphology and function have been recognized as a part of normal aging. Here, we sought to assess the effects of age on the retinal microglial and macrophage response to acute intraocular pressure (IOP) elevation. Further, we performed experiments whereby bone marrow from young or middle-aged mice was used t...
Source: Experimental Eye Research - Category: Opthalmology Authors: Tags: Exp Eye Res Source Type: research
During serial transplantation of bone marrow derived from young and aged donor CBA mice to 5-month-old recipients, the counts of multipotent stromal cells (MSC) in transplants from young donors assessed at each passage surpassed those of aged donors by 3.2, 7.8, 3.0, and 2.2 times attesting to the age-related decrease of active pool of bone marrow MSC. The medullary curettage in mouse femur increased the total number of MSC and the number of osteogenic MSC both in the contralateral femur and in the bone marrow transplants attesting to spread of the effects of osteogenic factors after bone injury onto the bone tissue of the...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
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