Sacubitril/Valsartan and Mexiletine: A Proarrhythmic Combination?

We report two cases that raise the possibility of an interaction between sacubitril/valsartan and the class Ib anti-arrhythmic mexiletine resulting in proarrhythmic effects. We discuss the pharmacokinetics of both agents and posit potential mechanistic interactions that suggest caution should be used and careful monitoring for (ventricular) arrhythmias applied in patients receiving sacubitril/valsartan and mexiletine.Cardiology 2019;142:4 –6
Source: Cardiology - Category: Cardiology Source Type: research