Isoleucine plays an important role for maintaining immune function.

Isoleucine plays an important role for maintaining immune function. Curr Protein Pept Sci. 2019 Mar 05;: Authors: Gu C, Mao X, Chen D, Yu B, Yang Q Abstract Branched chain amino acids are the essential nutrients for humans and many animals. As functional amino acids,they play important roles in physiological functions, including immune functions. Isoleucine, as one of the branched chainamino acids, is also critical in physiological functions of the whole body, such as growth, immunity, protein metabolism, fattyacid metabolism and glucose transportation. Isoleucine can improve the immune system, including immune organs, cells andreactive substances. Recent studies have also shown that isoleucine may induce the expression of host defense peptides (i.e.,β-defensins) that can regulate host innate and adaptive immunity. In addition, isoleucine administration can restore the effectof some pathogens on the health of humans and animals via increasing the expression of β-defensins. Therefore, the present review will emphatically discuss the effect of isoleucine on immunity while summarizing the relationship between branchedchain amino acids and immune functions. PMID: 30843485 [PubMed - as supplied by publisher]
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Tags: Curr Protein Pept Sci Source Type: research