Role of Autophagy in Chronic Liver Inflammation and Fibrosis.

Role of Autophagy in Chronic Liver Inflammation and Fibrosis.
Curr Protein Pept Sci. 2019 Mar 05;:
Authors: Tseng YJ, Dong L, Xu N, Ma W, Weng SQ, Janssen HLA, Wu SD
Abstract
Autophagy entails the removal of dysfunctional components to maintain cellular homeostasis. Over the years, studies of autophagy demonstrated its complex physiological and pathological roles in the liver. Apart from regulation of normal metabolic functions such as glycogenolysis, glycogenesis, and β-oxidation, autophagy also contributes to the modulation of various liver diseases. In this review, we provide a concise overview of the role of autophagy in regulating hepatic metabolism in healthy conditions and various chronic liver diseases. A well-rounded understanding of the role of autophagy may provide insight for future medical advancements in the field of hepatology.
PMID: 30843487 [PubMed - as supplied by publisher]

Source: Current Protein and Peptide Science - March 4, 2019 Category: Biochemistry Authors: Tseng YJ, Dong L, Xu N, Ma W, Weng SQ, Janssen HLA, Wu SD Tags: Curr Protein Pept Sci Source Type: research