Organizing pneumonia co ‐existing with carcinoid tumour: complete resolution with bronchoscopic tumour resection
We report an unusual case of organizing pneumonia occurring as a consequence of obstruction due to a carcinoid tumour and its complete resolution by bronchoscopic relief of obstruction without the need for steroid therapy. Organizing pneumonia is a well ‐known clinical entity resulting in response to noxious stimuli causing lung injury. It is known to occur with infectious disease processes, neoplasms, post lung surgery or radiation therapy and when idiopathic, is called cryptogenic organizing pneumonia. We present an unusual case of a 48‐year‐ old woman who presented with chronic cough and progressive dyspnoea while being on macrolide therapy for Lyme disease. Computerized tomography of chest demonstrated a well‐circumscribed nodule in the lingula and bilateral central ground glass opacities. Transbronchial biopsies were consistent with carcinoid tumour in the lingula and organizing pneumonia in bilateral lung fields. Bronchoscopic relief of obstruction was performed by mechanical debulking of the tumour, with subsequent complete resolution of bilateral opacities, consistent with resolution of organizing pneumonia without the need for steroid therapy.
Conclusions This review highlights the breadth of strategies that aim to preserve a patient ’ s bladder while still optimizing local tumor control and overall survival. Future areas for innovation include the use of predictive biomarkers and implementation of immunotherapy, moving the field towards patient-tailored care.
Publication date: Available online 20 February 2020Source: The Lancet Global HealthAuthor(s): Xin Wang, You Li, Katherine L O'Brien, Shabir A Madhi, Marc-Alain Widdowson, Peter Byass, Saad B Omer, Qalab Abbas, Asad Ali, Alberta Amu, Eduardo Azziz-Baumgartner, Quique Bassat, W Abdullah Brooks, Sandra S Chaves, Alexandria Chung, Cheryl Cohen, Marcela Echavarria, Rodrigo A Fasce, Angela Gentile, Aubree GordonSummaryBackgroundSeasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-viru...
We report an elderly male who presented with cough and fever and had pulmonary infiltrates suspicious of tuberculosis. Bronchoalveolar lavage microbiology including XpertMTB/Rif assay was non-contributory. Contrast enhanced computed tomography scan of abdomen revealed multiple non-enhancing lesions in the spleen. Ultrasound guided splenic aspirate revealed pus that was positive for Mycobacterium tuberculosis in XpertMTB/Rif assay confirming the diagnosis of tuberculosis. PMID: 32072799 [PubMed - in process]
Condition: Novel Coronavirus Pneumonia Intervention: Biological: NK Cells Sponsors: Xinxiang medical university; First Affiliated Hospital of Xinjiang Medical University Recruiting
Condition: Nosocomial Pneumonia Intervention: Diagnostic Test: Microbiological diagnostics on pulmonary secretion Sponsors: Zealand University Hospital; Slagelse Hospital Recruiting
Condition: Pulmonary Fibrosis Due to 2019-nCoV Interventions: Drug: N-acetylcysteine+ Fuzheng Huayu Tablet; Drug: N-acetylcysteine+Placebo Sponsors: ShuGuang Hospital; Hubei Hospital of Traditional Chinese Medicine; Jingmen No.1 People’s Hospital; Tongji Hospital Recruiting
ConclusionsP-IMRT produces relatively few higher-grade toxicities, and has reasonable disease-related outcomes, especially when delivering using conventionally-fractionated regimens to doses of 45-54 Gy and exercising careful attention to dose constraints during treatment planning. IMRT can thus be considered in well-selected patients in whom adequate survival following pleurectomy is expected. These data also support the initiation of the phase III NRG-LU006 trial of eP/D and chemotherapy with or without IMRT.
ConclusionIn this cohort of ESHL patients who responded completely to frontline therapy, the relapse rate was low. Routine imaging surveillance lacks clinical benefit in this patient population.
Publication date: Available online 20 February 2020Source: Journal of Clinical NeuroscienceAuthor(s): Waqar Haque, Yvonne Thong, Vivek Verma, Robert Rostomily, E. Brian Butler, Bin S. TehAbstractBackgroundGlioblastoma (GBM) presents as a solitary lesion (unifocal), or as multiple discrete lesions (multifocal). Multifocal GBM may have a worse prognosis as compared to unifocal GBM, but existing data are limited to small institutional series. The purpose of the present study was to evaluate demographic and clinical characteristics of patients with unifocal versus multifocal GBM to highlight demographic differences and clinica...
Conclusion: Eyes with retinoblastoma that failed chemotherapy followed by focal therapy were controlled with EBRT. However, the presence of vitreous seeds, stage migration during the course of chemotherapy, as well as good vision in the other eye may not justify the known risks of EBRT. PMID: 32072842 [PubMed - as supplied by publisher]