Variation in Transcutaneous Bilirubin Nomograms across Population Groups
Some degree of jaundice appears in the first postnatal days in the majority of infants born at ≥35 weeks of gestation.1,2 Usually the jaundice is mild and self-limited and may even be beneficial. In unusual cases, the result of lack of equilibrium between the bilirubin production and elimination processes, the serum total bilirubin may continue to rise.3 If untreated, extreme hyperbilirubi nemia may lead to bilirubin neurotoxicity (kernicterus spectrum disorder). Not surprisingly, acute bilirubin encephalopathy, death, choreoathetotic cerebral palsy, sensorineural hearing loss, and other manifestations of bilirubin neurotoxicity still occur in developing countries with inadequate me dical resources, or in regions affected by the ravages of war.
ConclusionsWe confirmed the genetic diagnosis of mevalonic aciduria caused by MVK deficiency which had been masked by liver disease and the possible misdiagnosis of alpha-1-antitrypsin deficiency.
AbstractHyperbilirubinemia is a common occurrence in neonates; it may be physiological or pathological. Conjugated hyperbilirubinemia may result from medical or surgical causes, and can result in irreversible liver damage if untreated. The aim of imaging is the timely diagnosis of surgical conditions like biliary atresia and choledochal cysts. Abdominal ultrasound is the first line imaging modality, and Magnetic resonance cholangiopancreatography (MRCP) also has a role, especially in pre-operative assessment of choledochal cysts (CDCs). For biliary atresia, the triangular cord sign and gallbladder abnormalities are the two...
Journal of Perinatology, Published online: 16 August 2019; doi:10.1038/s41372-019-0439-1Sixty years of phototherapy for neonatal jaundice – from serendipitous observation to standardized treatment and rescue for millions
ConclusionDelayed cord clamping in term and preterm infants was a simple, safe, and effective delivery procedure, which should be recommended, but the optimal cord clamping time remained controversial.
Conclusions: This international, novel, internally validated RRS accurately stratifies recurrence-free survival for patients with resected PanNETs. Given their unique recurrence patterns, surveillance intervals of 12, 6, and 3 months are proposed for low, intermediate, and high RRS patients, respectively, to minimize radiation exposure and optimize cost/resource utilization.
The leaves and bark of Syringa oblata Lindl are used as folk medicine which has heat-clearing, detoxifying, dampness-removing and jaundice-relieving effects. There are many studies about leaves of S. oblata becau...
AbstractBackgroundHypothyroidism with impairment of renal function and raised creatinine phosphokinase (CPK) is described in adults and children with acquired hypothyroidism, but not in congenital hypothyroidism.Case presentationA male infant born at term weighing 3390 g was seen aged 2 months with prolonged jaundice. Examination showed somnolence, umbilical hernia, enlarged fontanelles and lower limb edema; length 55 cm (−1.5 SD), weight 5.4 kg (−0.13 SD). Biochemistry showed fT4
In conclusion, oxidative stress can be a possible explanation of hepatic damage induced by chronic therapy with chlorpheniramine maleate and cetirizine hydrochloride.l-Carnitine has prominent hepatoprotective effects on chlorpheniramine maleate – and cetirizine hydrochloride–induced hepatic damage possibly through improvement of hepatic function and decreasing oxidative stress.
Publication date: Available online 13 August 2019Source: Journal of Neonatal NursingAuthor(s): Pascalin Tiam Kapen, Youssoufa Mohamadou, Foutse Momo, Dongmeza Koudjou Jauspin, Nenkam Kanmagne, Dongmeza Dongmo JordanAbstractThis paper aims to develop an automatic neonatal incubator equipped with phototherapy, biometric fingerprint reader, remote monitoring and heart rate control modules for developing countries due to the lack of neonatal incubators. The proposed device consists of an acquisition module that senses temperatures (of the enclosure and the baby) and humidity, a biometric fingerprint reader to identify the user...
ConclusionAlthough the mechanism by which this occurs in some cases is unclear, early identification and prompt fluid resuscitation prevent acute kidney injury. The adoption of new strategies for internal drainage of long complex strictures will both prevent and ameliorate this problem.