An Antibody-Inspired Small Molecule Could Make For A Better Flu Treatment

To outsmart influenza, researchers are leveraging the biological information encoded in infection-fighting antibodies to design new drugs. One attempt neutralizes near-lethal levels of flu in mice.(Image credit: Steve Gschmeissner/Science Source)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news

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Condition:   Influenza Intervention:   Diagnostic Test: MCC IMS Sponsor:   Klinikum Bayreuth GmbH Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Source: BMJ Comments - Category: General Medicine Source Type: forums
Child influenza-related deaths at this point in the season are the second highest since such deaths were made a nationally notifiable condition in 2004.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
A surge in deadly coronavirus cases outside China is raising concerns that the outbreak has reached a new stage and could continue its global spread to even more vulnerable countries. In the central Chinese province of Hubei, where the virus is believed to have originated, the number of cases appears to be stabilizing, according to government figures. But the number of people infected elsewhere in the world is rising quickly, with clusters in South Korea, Italy, Iran and a cruise ship docked in Japan. As of Monday, more than 2,200 cases of the virus, officially called COVID-19, have been reported outside of mainland China,...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 onetime overnight Source Type: news
(University of Barcelona) Two studies led by the UB analyzed several aspects involved in the detection of the influenza: the utility of the definition of the illness considering clinical manifestation and complementarity of supervision systems based on severe ambulatory cases that require hospitalization in Catalonia. Moreover, they also studied the features of the cases that were detected in Catalonia among children and teenagers who are under eighteen years old.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsThough the number of pro-vaccine posts increased, antivaccine posts remained more popular. The government agency may use an emotive personal family-oriented message to promote vaccination.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Publication date: Available online 22 February 2020Source: Pharmacology &TherapeuticsAuthor(s): Kimiyasu Shiraki, Tohru DaikokuAbstractFavipiravir has been developed as an anti-influenza drug and licensed as an anti-influenza drug in Japan. Additionally, favipiravir is being stockpiled for 2 million people as a countermeasure for novel influenza strains. This drug functions as a chain terminator at the site of incorporation of the viral RNA and reduces the viral load. Favipiravir cures all mice in a lethal influenza infection model, while oseltamivir fails to cure the animals. Thus, favipiravir contributes to curing an...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Pulmonary endothelial cells (ECs) are an essential component of the gas exchange machinery of the lung alveolus. Despite this, the extent and function of lung EC heterogeneity remains incompletely understood. Using single-cell analytics, we identify multiple EC populations in the mouse lung, including macrovascular endothelium (maEC), microvascular endothelium (miECs), and a new population we have termedCar4-high ECs.Car4-high ECs express a unique gene signature, and ligand-receptor analysis indicates they are primed to receive reparative signals from alveolar type I cells. After acute lung injury, they are preferentially ...
Source: eLife - Category: Biomedical Science Tags: Stem Cells and Regenerative Medicine Source Type: research
"We are excited with the launch of the quadrivalent version of our flu vaccine, which can be offered to both children above six months and adults. This particular type of vaccine provides good immune response with less side-effects," Abbott India Medical Director Srirupa Das said.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
AbstractPurpose of ReviewWe reviewed the benefit of influenza vaccination in healthcare personnel (HCP), rates of vaccine coverage, and practices used to try to boost vaccine coverage among HCP.Recent FindingsInfluenza vaccination in HCP provides benefits to both HCP and patients, including reductions in patient morbidity and mortality and decreases in HCP absenteeism. Despite these benefits, influenza vaccine coverage among HCP still falls short of the Healthy People 2020 goal of 90%. As a result, healthcare institutions have used various practices to boost vaccination, including mandatory vaccine policies and requiring n...
Source: Current Treatment Options in Infectious Diseases - Category: Infectious Diseases Source Type: research
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