Role of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Cancer Prevention and Cancer Promotion.

Role of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Cancer Prevention and Cancer Promotion. Adv Pharmacol Sci. 2019;2019:3418975 Authors: Wong RSY Abstract The nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed by medical practitioners in many clinical conditions for the symptomatic treatment of pain and fever. Due to their anti-inflammatory properties, these drugs have been investigated for their anticancer effects in numerous studies. This is because chronic inflammation has long been linked to carcinogenesis. As such, anti-inflammatory drugs are believed to play a role in cancer treatment and prevention. In the past few decades, research has shown that NSAIDs may decrease the risk of certain types of cancer. However, there is also a growing body of research that proves the contrary. Furthermore, NSAIDs are well known for many side effects, including some life-threatening ones. This review will discuss the relationship between chronic inflammation and cancer, the role of NSAIDs in cancer prevention and cancer promotion, and some of the potentially lethal side effects of these drugs. PMID: 30838040 [PubMed]
Source: Advances in Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

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Conclusion: Further work is needed in this area of research. Future studies should control for patient characteristics, time elapsed between diagnosis and baseline assessment and evaluate their contribution to the presence of response shift. Time between assessments should include short and longer periods between assessments and evaluate whether the presence of response shift holds over time. Possible avenues for inquiry for future investigation are discussed.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Staying healthy is best done with expert help. We all need medical care at some point. And if chronic illness strikes, it requires the guidance of someone with the ability to make diagnoses and balance treatments that are often aimed at different organ systems. Primary care physicians (PCPs) are generalists who see adult patients for common ailments including respiratory infections, headaches, back pain, and urinary infections. They also manage chronic conditions such as high blood pressure, diabetes, heart disease, obesity, anxiety, and depression. In addition, PCPs have expertise in managing multiple treatments, medicati...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
CONCLUSION: Patients and caregivers have similar perceptions of needs at diagnosis. A supportive healthcare team can positively influence patients' QoL, highlighting the importance of tailoring support according to needs. PMID: 31423539 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - Category: General Medicine Authors: Tags: Singapore Med J Source Type: research
ConclusionLow-volume prescribers in the social network ’s periphery were at greater risk of intended or discoordinated prescribing than interconnected high-volume prescribers. Interventions addressing discoordination among low-volume opioid prescribers in non-integrated practices should be a priority. Demands for enhanced functionality and integration of Prescription Drug Monitoring Programs or referrals to specialized multidisciplinary pain management centers are potential policy implications.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
In this episode, Gabe talks with editor-in-chief Dr. John Grohol about the importance of planning for the end of life.  We all know that everybody dies, but at the same time, no one wants to think about their own inevitable death. Do you know how you would like the end of your life to go?  What if you needed to make that decision for a loved one? Do you know what they want? Would they want to be resuscitated? Do they want to die at home or in a hospital? Do you even know what kinds of decisions need to be made, or what the options are?  Listen in as Dr. John explains that there is a degre...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Death & Dying General LifeHelper The Psych Central Show Source Type: blogs
Editor ’s PerspectiveWhat We Already Know about This TopicPectoralis-II block is a potential alternative to paravertebral blocks to provide regional analgesia for breast cancer surgeryWhat This Article Tells Us That Is NewThis meta-analysis includes 14 randomized trials comparing pectoralis-II block with paravertebral blocks and found that there were no differences in pain scores or opioid consumption between the two groups in patients having surgery for breast cancerPectoralis-II blocks were noninferior to paravertebral blocks in reducing pain intensity and morphine consumption for the first 24 h after surgery and b...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
The first-ever human trial of a genital-chlamydia vaccine suggests that it is safe and effective, according to a new study published in the Lancet. U.S. sexually transmitted illness diagnoses have reached new highs for the past four years in a row, and chlamydia is responsible for the bulk of those infections: 1.7 million cases were diagnosed in 2017 alone, according to the U.S. Centers for Disease Control and Prevention, compared to about 550,000 cases of gonorrhea, 40,000 cases of HIV and 30,000 cases of syphilis. Globally, the problem is even more widespread: about 127 million cases were diagnosed in 2016, according to ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized embargoed study Research Source Type: news
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined. Mean nonfasting cholesterol concentration was 72...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Chronic pancreatitis (CP) is a pancreatic disease with poor prognosis characterized clinically by abdominal pain, morphologically by pancreatic stones/calcification, duct dilatation and atrophy, and functionally by pancreatic exocrine and endocrine insufficiency. CP is also known as a risk factor for the development of pancreatic cancer. CP has long been understood based on a fixed disease concept deduced from the clinical and morphological features of the end-stage disease. However, identification of causal genes for hereditary pancreatitis and success in the isolation and culture of pancreatic stellate ...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
Abstract The intent of this article is to help clinicians to have practical knowledge and skills related to both assessment and pharmacotherapy of chronic pain in the seriously ill patients. Treating patients with chronic pain and progressive disease should include assessment of "total pain" (physical, psychological, and spiritual suffering) and the care givers as part of treatment team. Effective management of chronic pain starts with thorough assessment and diagnosis of the pain syndrome. A worldwide consensus endorses use of multimodal approach and opioid pharmacotherapy as the mainstay approach to mo...
Source: Primary Care - Category: Primary Care Authors: Tags: Prim Care Source Type: research
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