A Western Diet, but Not a High-Fat and Low-Sugar Diet, Predisposes Mice to Enhanced Susceptibility to Imiquimod-Induced Psoriasiform Dermatitis

Psoriasis is a disease with systemic inflammation and accompanied by multiple comorbidities, including metabolic syndrome and obesity (Hwang et  al., 2017; Tsai et al., 2017; Yu et al., 2017). Obesity is often observed in patients with psoriasis and may precede development of psoriasis (Debbaneh et al., 2014). Western diet (WD) plays a crucial role in the development of obesity in Western countries and is characterized by elevated amoun ts of fat and sugars, especially simple sugars such as sucrose (Jena et al., 2017).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research