Prognostic value of low CDX2 expression in colorectal cancers with a high stromal content – a short report

ConclusionsThe present study confirms a poor outcome of patients with stroma-high tumours. Low CDX2 expression in tumours with a high stromal content identified patients with a particularly poor prognosis. The present study did not reveal a clear difference in TSR associated with CDX2 status and survival. This method, solely based on microscopy, identifies patients who have a high risk of relapse and a poor outcome, and who may benefit from targeted therapy.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research

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Authors: Kajiyama H, Suzuki S, Utsumi F, Nishino K, Niimi K, Mizuno M, Yoshikawa N, Kawai M, Oguchi H, Mizuno K, Yamamuro O, Shibata K, Nagasaka T, Kikkawa F Abstract Malignant ovarian neoplasm is one of the most lethal malignancies among cancers of the female reproductive system. Occasionally, these tumors originate from non-ovarian organs as metastatic lesions since the ovary is a frequent metastatic target of many cancers. However, there limited clinical information on metastatic ovarian carcinoma (MOC) and its hallmarks are unknown. During the period of 1986-2015, 4,284 patients with malignant ovarian neoplasm ...
Source: Nagoya Journal of Medical Science - Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research
Health-Related Complications of Acromegaly—Risk of Malignant Neoplasms Marek Ruchala*† and Kosma Wolinski† Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznań, Poland The issue of increased risk of benign and malignant neoplasms in patients with acromegaly remains the topic of debate from many years and was addressed by numerous studies. Many of them have shown increase in the cancer incidence. Among particular types of malignancies, thyroid, colorectal, and breast cancer are most commonly indicated as associated with acromegaly. Single ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
The final diagnosis of ovarian cancer is based on surgery and pathological verification. Therefore patients who are presented to surgery may be described only as supposed ovarian cancer. According to the literature the diagnosis of ovarian cancer is confirmed only in 2/3 of them. The rest are that which mimic ovarian cancer. One of them is colorectal cancer. Colonoscopy is a gold standard in its diagnostics. On the other hand, ovarian cancer may disturb the bowel patency and makes the bowel resection or stoma necessary. The main aim was to find out the distribution of bowel patency disturbances in ovarian cancer patients ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
ConclusionsAnalysis of these data suggests that minimally invasive approach for peritonectomy procedures and HIPEC is feasible, safe and should be considered as part of the armamentarium for highly selected patients with peritoneal surface malignancies with limited tumour burden, defined as PCI of 10 or less and borderline tumours as low-grade pseudomyxoma and benign multicystic mesothelioma.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
CONCLUSION: A combination of tissue overexpression of MUC1, reduced MUC2 expression, and high ratio of MUC1/MUC2 is a factor of poor prognosis in CRC patients. MUC2 tissue expression allows to differentiate mucinous and nonmucinous CRC subtypes. PMID: 30271081 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
CONCLUSIONS: There was no evidence of increased risk of developing dMMR CRC after CCY although a borderline significantly increased 2-fold risk was observed 10-20 years after CCY. Larger studies are warranted to examine this further. PMID: 30010450 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conclusions: FDG PET/MRI shows promise for response evaluation following NAT with complete metabolic response by PET/MRI correlating with marked or complete pathologic response.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: GI Non-Colorectal Posters Source Type: research
Conclusions: While FDG PET successfully identified CRC recurrences without serial CEA elevations, there was no significant link between site of FDG avid metastatic recurrence and CEA doubling times/ rising titers. The significant correlation between final diagnosis and rising CEA titers may be useful while planning imaging. Sigmoid and rectosigmoid carcinomas are more than 80% likely to have rising CEA titers while solely Rectal carcinoma was only 51% as likely, indicating a bigger role for PET/CT in the latter cases. CRC Subtype Diagnosis vs. CEA titersFinal Diagnosis Rising CEA Titers (Yes)Rising CEA Titers (No)Tota...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: GI- Colorectal and Liver Source Type: research
Authors: Dvorak J, Hadzi Nikolov D, Dusek L, Filipova A, Richter I, Buka D, Ryska A, Mokry J, Filip S, Melichar B, Buchler T, Abrahamova J Abstract PURPOSE: Primary cilium (PC) is considered to be a functional homologue of the immune synapse. Microtubule structures, PC of cancer associated fibroblasts and immune synapses between cytotoxic CD8+ tumor infiltrating lymphocytes (TILs) and cancer cells, are regularly found in varying amounts in the microenvironment of solid tumors. The purpose of this study was to find out the potential association and combined prognostic significance of the frequency of PC, PD-1 and CD...
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
This report supports SATB2 as an additional diagnostic marker for the diagnosis of an ovarian manifestation of LAMN.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
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