Allergen-specific CD8+ T cells in peanut-allergic individuals
CD8+ T cells are uncommonly thought to be involved in IgE-mediated food allergy, but there are reasons to reconsider their role in this condition.1 CD8+ T cells are present in skin, and in the respiratory and gut mucosae, where they may modulate the immune response in atopic conditions such as asthma and atopic dermatitis.2-4 In mice, CD8+ T cells attenuate food allergy in some experimental models, whereas in humans, CD8+ T cells have been shown to expand in response to wheat ingestion in celiac disease.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Wong Yu, Xiaoying Zhou, Diane Dunham, Shu Chen Lyu, Monali Manohar, Wenming Zhang, Fan Zhao, Mark M. Davis, Kari Nadeau Tags: Letter to the Editor Source Type: research
More News: Allergy | Allergy & Immunology | Asthma | Celiac Disease | Coeliac Disease | Dermatitis | Dermatology | Food Allergy | Peanuts | Respiratory Medicine | Skin | Wheat