Central Sensitization in Knee Osteoarthritis: Relating Presurgical Brainstem Neuroimaging and PainDETECT ‐Based Patient Stratification to Arthroplasty Outcome
ConclusionThe psychophysical and neuroimaging data suggest that a subset of OA patients have centrally mediated pain sensitization. This was likely due to supraspinally mediated reductions in inhibition and increases in facilitation of nociceptive signaling, and was associated with a worse outcome following arthroplasty. The neurobiologic confirmation of central sensitization in patients with features of neuropathic pain, identified using PainDETECT, provides further support for the investigation of such bedside measures for patient stratification, to better predict postsurgical outcomes.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Anushka Soni,
Vishvarani Wanigasekera,
Melvin Mezue,
Cyrus Cooper,
Muhammad K. Javaid,
Andrew J. Price,
Irene Tracey Tags: Original Article Source Type: research
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