Millions of women who take HRT pills may face a greater risk of Alzheimer's, warns study
An estimated one million women in Britain and five per cent of women over the age of 50 in the US take hormone replacement therapy to help relieve menopause symptoms.
Research, published in theThe BMJ, suggests that HRT treatment for menopause may slightly increase a women’s risk of developing Alzheimer’s disease.News Weeks
' For women in early menopause with bothersome vasomotor symptoms, no compelling evidence exists of cognitive concern from randomized trials,'but'concerns about longer-term use'remain, say experts.Medscape Medical News
THURSDAY, March 7, 2019 -- Many women turn to hormone therapy to ease some of the more troubling symptoms of menopause, such as hot flashes and night sweats. But new research suggests that relief may come at a cost -- an increased risk of...
The risk is very low and drugs to treat menopause symptoms are safe and effective, doctors say.
Although historically considered two distinct entities, both vascular dementia (VD) and Alzheimer's Dementia (AD) are associated with increased odds of cerebrovascular disease. While early-onset AD (
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In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model. Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the 'physiologic reserve' of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokin...
lli D Abstract Circulating ceramide levels are abnormally elevated in age-dependent pathologies such as cardiovascular diseases, obesity and Alzheimer's disease. Nevertheless, the potential impact of age on plasma ceramide levels has not yet been systematically examined. In the present study, we quantified a focused panel of plasma ceramides and dihydroceramides in a cohort of 164 subjects (84 women) 19 to 80 years of age. After adjusting for potential confounders, multivariable linear regression analysis revealed a positive association between age and ceramide (d18:1/24:0) (β (SE) = 5.67 (2.38); p = .0198) a...
No abstract available
Conclusions: In a general population of postmenopausal women, association between poor metabolic profile with reduction in cognitive performance is more apparent in women who carry an ApoE4 allele. These data indicate a window of opportunity for interventions to reverse the trajectory of the preclinical phase of Alzheimer's disease.