The study of cellular mechanism of triptolide in the treatment of cancer, bone loss and cardiovascular disease and triptolide's toxicity.

The study of cellular mechanism of triptolide in the treatment of cancer, bone loss and cardiovascular disease and triptolide's toxicity. Curr Stem Cell Res Ther. 2019 Mar 01;: Authors: Wang Y, Wang B, Yang X Abstract Triptolide (TPL), the active component of Tripterygium wilfordii Hook F (Twhf) has been used to treat cancer and bone loss conditions for over two hundred years in traditional Chinese medicine (TCM). In this paper, we reviewed the specific molecular mechanisms in the treatment of cancer, bone loss and cardiovascular disease. In addition, we analyze the toxicity of TPL and collect some optimized derivatives extracted from TPL. Although positive results were obtained in most cell culture and animal studies, further studies are needed to substantiate the beneficial effects of TPL. PMID: 30834841 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research