Multi-Epitope Fusion Protein Eg mefAg-1 as a Serodiagnostic Candidate for Cystic Echinococcosis in Sheep.

Multi-Epitope Fusion Protein Eg mefAg-1 as a Serodiagnostic Candidate for Cystic Echinococcosis in Sheep. Korean J Parasitol. 2019 Feb;57(1):61-67 Authors: Tianli L, Xifeng W, Zhenzhong T, Lixia W, Xingxing Z, Jun Q, Qingling M, Shasha G, Ying C, Xuepeng C Abstract Cystic echinococcosis (CE) in sheep is a hazardous zoonotic parasitic disease that is caused by Echinococcus granulosus (Eg). At present, serological test is an important diagnostic method for Eg infection in domestic animals. Here, a fusion protein Eg mefAg-1 harboring 8 dominant B-cell epitopes of Eg such as antigen B, tetraspanin 1, tetraspanin 6, reticulon and Eg95 was produced in E. coli and evaluated for CE in sheep by indirect ELISA. Eg mefAg-1 showed in ELISA a high sensitivity (93.41%) and specificity (99.31%), with a coincidence rate of 97.02%. Overall, it is suggested that the Eg mefAg-1 could be a potential antigen candidate for CE serodiagnosis in sheep. PMID: 30840802 [PubMed - in process]
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research

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ConclusionThese results indicate that A. farnesiana pods contain nematocidal compounds and might be promising natural anthelmintic agents against H. contortus. This leguminous plant could be used as a nutraceutical food source for the control of gastrointestinal nematodes in small ruminants.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsWe found that EFVF is safe with regard to acute toxicity in rats as well as genotoxicity such as mutagenesis or clastogenesis under the present experimental conditions. These results might support the safety of EFVF as a potential therapeutic material for the traditional use or pharmaceutical development.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: in Mexico, there is a very low prevalence of PI-IBS in patients from a tertiary-referral center. However, it varies according to the surrogate-criteria used. The later needs to be taken into account when performing PI-IBS studies. PMID: 31718206 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
ConclusionThis is the first report on the synthesis of two novel ginsenosides, namely glucosyl-ginsenoside Rh2 and diglucosyl-ginsenoside Rh2 from Rh2 by utilizing recombinant glycosyltransferase isolated from L. rhamnosus. Moreover, diglucosyl-ginsenoside Rh2 might be a new candidate for treatment of inflammation, obesity and skin whiting, and especially for anticancer.Graphical abstract
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
Publication date: 14 November 2019Source: Cell, Volume 179, Issue 5Author(s): Rebecca R. Stanway, Ellen Bushell, Anush Chiappino-Pepe, Magali Roques, Theo Sanderson, Blandine Franke-Fayard, Reto Caldelari, Murielle Golomingi, Mary Nyonda, Vikash Pandey, Frank Schwach, Séverine Chevalley, Jai Ramesar, Tom Metcalf, Colin Herd, Paul-Christian Burda, Julian C. Rayner, Dominique Soldati-Favre, Chris J. Janse, Vassily HatzimanikatisSummaryPlasmodium gene functions in mosquito and liver stages remain poorly characterized due to limitations in the throughput of phenotyping at these stages. To fill this gap, we followed...
Source: Cell - Category: Cytology Source Type: research
Publication date: March 2020Source: Food Packaging and Shelf Life, Volume 23Author(s): Afsaneh Nouri, Mohammad Tavakkoli Yaraki, Aseman Lajevardi, Tayyebeh Rahimi, Marjan Tanzifi, Mohammad GhorbanpourAbstractIn the present research, biodegradable κ- carrageenan (KC) nanocomposite film was prepared by incorporation nanoclay, 1–3% v/v of Zataria multiflora plant extract (ZME) and glycerol as a plasticizer via two different procedures. The nanocomposite films were characterized by their optical, microstructural, mechanical and thermal as well as antimicrobial properties against S. aureus, B.cereus, E.coli, and P. ...
Source: Food Packaging and Shelf Life - Category: Food Science Source Type: research
Abstract Healthcare-associated infections (HAIs) not only bring additional medical cost to the patients but also prolong the length of stay (LOS). 2119 HAI case-patients and 2119 matched control-patients were identified in 68 hospitals in 14 primary sampling provinces of 7 major regions of China. The HAI caused an increase in stay of 10.4 days. The LOS due to HAI increased from 9.7 to 10.9 days in different levels of hospitals. There was no statistically significant difference in the increased LOS between different hospital levels. The increased LOS due to HAI in different regions was 8.2 to 12.6 days. Comparing b...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
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Source: BioImpacts - Category: Research Tags: Bioimpacts Source Type: research
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