Mutagenetic and anti-allergic studies for evaluation of extracts of Coptis Rhizome produced by an artificial hydroponic system

AbstractAs a part of the investigation of the safety and efficacy of the cultivatedCoptis japonica rhizome extracts using an artificial hydroponic cultivation system, the mutagenetic and anti-allergic activities were evaluated. Some extracts of commercial crude drugs ofCoptis sp. were also evaluated for the comparison. None of the extracts showed a significant mutagenicity inSalmonella typhimurium TA102 by the Ames tests, but all the extracts showed inS. typhimurium TA98. The extracts of the hydroponically cultivated rhizomes showed anti-allergic activities against contact hypersensitivity as well as those of commercial crude drugs ofCoptis sp. These results suggested the potential of the hydroponically cultivated rhizomes as one of the alternative sources for the medicinal usage.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research