Flavonoids isolated from the flowers of Pulsatilla flavescens and their anti-piroplasm activity

AbstractPulsatilla species are known as “Yargui”, and their flowers are traditionally used in Mongolia as a tonic and for the treatment of inflammatory diseases. By chemical investigation ofP.flavescens flowers, 21 flavonoids, including a new chalconeC-glucoside, chalconaringenin 2 ′-O- β-d-glucopyranosyl-5 ′-β-d-glucopyranoside, and two new flavanoneC-glucosides, (2R)- and (2S)-naringenin 8- β-d-glucopyranosyl-4 ′-O- β-d-glucopyranoside, were isolated. The absolute configurations of the seven flavanone glucosides were elucidated by ECD spectra. For the isolated compounds, inhibitory activity againstBabesia caballi andTheileria equi, which cause fatal diseases in horses, was estimated. Although most of the isolated chalcone and flavanone derivatives did not show any anti-piroplasm activity, all the isolated flavone and flavonol derivatives showed moderate effects againstB. caballi and/orT. equi.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research