Effects of spaceflight on heart cell formation from stem cells

(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers used time-lapse imaging to show that mouse induced pluripotent stem cells (iPSCs) grown during spaceflight differentiated into cardiomyocytes significantly faster than similar cells grown at Earth's gravity.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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I recently attended the second Ending Age-Related Diseases conference in New York, hosted by the Life Extension Advocacy Foundation (LEAF). The mix of attendees was much the same as last year: an even split between scientists, entrepreneurs, investors, patient advocates, and interested onlookers, all focused on the treatment of aging as a medical condition. The presentations were similarly a mix of scientists talking about their research programs, entrepreneurs presenting on the data produced by their companies, and investors discussing the state of the industry. For my part, I have already presented several times t...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Conclusion: This study found that there were no significant differences in QoL or level of depression between HSCT survivors and their spouse caregivers. Family income, gender, and co-morbidities showed significant association with spouse caregiver distress. PMID: 31309093 [PubMed]
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
Conclusion: Our study showed that bendamustine is a potentially toxic agent in the conditioning regimen for autologous SCT, resulting in significant liver, kidney, and gastrointestinal toxicity. Further studies are required to assess its safety and efficacy at reduced doses. PMID: 31309088 [PubMed]
Source: Blood Research - Category: Hematology Tags: Blood Res Source Type: research
Conditions:   Allogeneic Hematopoietic Stem Cell Transplant Recipient;   Donor;   Hematopoietic and Lymphoid Cell Neoplasm Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Drug: Bendamustine;   Drug: Bendamustine Hydrochloride;   Drug: Cyclophosphamide;   Biological: Filgrastim-sndz;   Drug: Fludarabine;   Drug: Fludarabine Phosphate;   Drug: Melphalan;   Drug: Mycophenolate Mofeti l;   Biological: Rituximab;   Drug: Tacrolimus;   Ra...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 16 July 2019Source: Stem Cell ResearchAuthor(s): Laura Arribas-Carreira, Irene Bravo-Alonso, Arístides López-Márquez, Esmeralda Alonso-Barroso, Álvaro Briso-Montiano, Ignacio Arroyo, Magdalena Ugarte, Belén Pérez, Celia Pérez-Cerdá, Pilar Rodríguez-Pombo, Eva RichardAbstractA human induced pluripotent stem cell (iPSC) line was generated from fibroblasts of a patient with nonketotic hyperglycinemia bearing the biallelic changes c.1742C > G (p.Pro581Arg) and c.2368C > T (p.Arg790Trp) in the GLDC gene. Reprogramming...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 16 July 2019Source: Stem Cell ResearchAuthor(s): Lauren R. Moore, Laura Keller, David D. Bushart, Rodrigo Delatorre, Dorcas Li, Hayley S. McLoughlin, Maria do Carmo Costa, Vikram G. Shakkottai, Gary D. Smith, Henry L. PaulsonAbstractSpinocerebellar ataxia type 3 (SCA3) is a fatal, late-onset neurodegenerative disorder characterized by selective neuropathology in the brainstem, cerebellum, spinal cord, and substantia nigra. Here we report the first NIH-approved human embryonic stem cell (hESC) line derived from an embryo harboring the SCA3 mutation. Referred to as SCA3-hESC, this line is h...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: 16 July 2019Source: Cell Reports, Volume 28, Issue 3Author(s): Liang Li, Xiangbin Ruan, Chang Wen, Pan Chen, Wei Liu, Liyuan Zhu, Pan Xiang, Xiaoling Zhang, Qunfang Wei, Lin Hou, Bin Yin, Jiangang Yuan, Boqin Qiang, Pengcheng Shu, Xiaozhong PengSummaryHistone methylation is essential for regulating gene expression during organogenesis to maintain stem cells and execute a proper differentiation program for their descendants. Here we show that the COMPASS family histone methyltransferase co-factor ASH2L is required for maintaining neural progenitor cells (NPCs) and the production and positioning of projecti...
Source: Cell Reports - Category: Cytology Source Type: research
This popular science article from the AARP is representative of the sort of outsider's view of the longevity industry that is presently dominant. On the one hand, it is good that the media and advocacy organizations such as AARP are finally talking seriously about treating aging as a medical condition. On the other hand, the author looks at two of the most popular areas of development, mTOR inhibitors and senolytics, in a way that makes them seem more or less equivalent, and then further adds diet and exercise as another equivalent strategy. This will be continuing issue, I fear. People, as a rule, don't think about size o...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
In this study, researchers worked in the lab with the yeast Saccharomyces cerevisiae to investigate how the dosage of histone genes would affect longevity. They expected that yeast genetically engineered to carry fewer copies of certain histone genes than normal or control yeast would have chromatin changes that would result in the yeast living less than controls. "Unexpectedly, we found that yeast with fewer copies of histone genes lived longer than the controls." Yeast with a moderately low dose of histone genes showed a moderate reduction of histone gene expression and significant chromatin stress. Their respo...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Authors: Didier K, Robbins A, Antonicelli F, Pham BN, Giusti D, Servettaz A Abstract Systemic sclerosis is a rare connective tissue disease characterized by skin and several internal organ fibrosis, systemic vasculopathy and immune abnormalities. Even if fibroblasts and endothelial cells dysfunction, as well as lymphocytes and other immune cells implication are now well described, the exact origin and chronology of the disease pathogenesis remain unclear. Oxidative stress, influenced by genetic and environmental factors, seems to play a key role. Indeed, it seems to be implicated in the early phases of fibrosis dev...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
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