Enigmatic gender difference in cancer incidence: evidences from childhood cancers.

Enigmatic gender difference in cancer incidence: evidences from childhood cancers. Am J Epidemiol. 2019 Mar 05;: Authors: Liu Z, Yang Q, Cai N, Jin L, Zhang T, Chen X Abstract We aimed to investigate the differences in cancer incidence between boys and girls. The incidence data for pediatric cancer were retrieved from the International Incidence of Childhood Cancer. Poisson regression was applied to detect the gender differences in cancer incidence at global and regional levels. Boys were more susceptible to childhood cancers than girls, with a global boy-to-girl incidence rate ratio (IRR) of 1.27 (95% confidence intervals [CI] 1.26-1.28) for leukaemia, 1.48 (95% CI 1.46-1.51) for lymphomas, 1.10 (95% CI 1.08-1.11) for central nervous system neoplasms, 1.11 (95% CI 1.08-1.13) for neuroblastoma, 1.05 (95% CI 1.02-1.09) for retinoblastoma, and 1.39 (95% CI 1.33-1.45) for hepatic tumors, respectively. Girls were only predominant in renal tumors (IRR = 0.90, 95% CI 0.88-0.92). Significant gender differences were observed in childhood cancers based on global-scale cancer data. The most pronounced disparities were mostly observed in developing countries, highlighting the data registration quality should be improved and attention was needed for health care access and service utilization for girls in these regions. Additionally, given the limited exposures to environmental risk factors in children, the differences might be mainly attributabl...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research