Phosphodiesterase-5 (PDE-5) Inhibitors and Ototoxicity: A Systematic Review

Conclusions: Currently, the literature is inconclusive regarding the interaction between PDE-5 inhibitor use and ototoxicity. Future study such as a double-blinded placebo controlled randomized trial with audiometric assessment would provide more sound evidence. Similarly, a unified molecular model is necessary.
Source: Otology and Neurotology - Category: ENT & OMF Tags: REVIEW ARTICLE Source Type: research