Ezh2 controls development of natural killer T cells that cause spontaneous asthma-like pathology

The epigenetic regulator Ezh2 suppresses development of an IL-4-expressing natural killer T cell population that causes hyper-IgE, airway inflammation and airway hyperreactivity in mice.

Source: Journal of Allergy and Clinical Immunology - March 5, 2019 Category: Allergy & Immunology Authors: Damon Tumes, Kiyoshi Hirahara, Magdalene Papadopoulos, Kenta Shinoda, Atsushi Onodera, Jin Kumagai, Kwok Ho Yip, Harshita Pant, Kota Kokubo, Kiuchi Masahiro, Ami Aoki, Kazushige Obata-Ninomiya, Koji Tokoyoda, Yusuke Endo, Motoko Y. Kimura, Toshinori Nakay Source Type: research