Down-Regulation of Renal Klotho Expression by Shiga Toxin 2

Conclusion: Shiga toxin 2 treatment stimulated Tnfα transcription, down-regulated renal klotho expression and increased FGF23 formation, effects presumably contributing to renal tissue injury.Kidney Blood Press Res 2014;39:441-449
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research