Clinicopathological Features of ALK Expression in 9889 Cases of Non-small-Cell Lung Cancer and Genomic Rearrangements Identified by Capture-Based Next-Generation Sequencing: A Chinese Retrospective Analysis

ConclusionsYounger patients with NSCLC, especially those aged  <  30 years, were more likely to test positive for ALK. Positive ALK test results were more common in patients with invasive mucinous adenocarcinoma and solid-predominant invasive adenocarcinoma than in patients with other histotypes. Samples that carried only noncanonicalALK rearrangements may also have carried the canonicalEML4-ALK, which was not detected by capture-based NGS.EML4-ALK transcripts might result from rare splicing mechanisms without genomic rearrangements.
Source: Molecular Diagnosis and Therapy - Category: Molecular Biology Source Type: research