Modeling individual time courses of thrombopoiesis during multi-cyclic chemotherapy

ConclusionsWe propose a mechanistic thrombopoiesis model of unprecedented comprehensiveness in both, biological mechanisms considered and experimental data sets explained. Our innovative method of parameter estimation allows robust determinations of individual parameter settings facilitating the development of individual treatment adaptations during chemotherapy.

Source: PLoS Computational Biology - March 5, 2019 Category: Biology Authors: Yuri Kheifetz Source Type: research