Synthesis, characterization and antitumor activity of (E)-2-methyl-3-ferrocenyl-N-acrylamide derivatives

We report here the synthesis, characterization of seventeen (E)-2-methyl-3-ferrocenyl-N-acrylamides. The single crystal structures of the key intermediate b and two target compounds d5 and d6 were confirmed by X-ray crystallographic analysis. Antitumor activity of all compounds was tested in vitro. Compound d1 was the most significant one against B16-F10 cell line, indicating that it could be a good candidate for further study. Furthermore, cancer cell apoptosis assay was performed and the result indicated that compound d1 effectively fueled B16-F10 cells apoptosis in a dose-dependent manner.Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research