Eosinophilic oesophagitis (in nickel-allergic patient) regressed after nickel oral desensitization: A case report.

We describe the case of a 48-year-old woman suffering from EoE not responsive to the topical steroid administration and diagnosis of SNAS. The patient started nickel oral desensitization according to the literature protocol continuing nickel-free diet. After 1 year from the beginning of the treatment, during the maintenance dose (500 ng three times a week), she decreased gradually the dosage of immunotherapy and reintroduced all the culprit foods. After the immunotherapy interruption, during the free diet, she repeated the oesophagogastroscopy with a complete macroscopic and histological resolution. We showed the first case of an EoE in a patient affected by SNAS responsive to the nickel-free diet and the oral immunotherapy. PMID: 30834798 [PubMed - in process]
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research

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This article will discuss the available evidence on allergen immunotherapy and biologic drugs in pediatric asthma treatment. Expert opinion: Previously published studies demonstrated a good efficacy and safety profile of Allergen Immunotherapy in patients with mild-moderate asthma and sensitization to one main allergen. New understanding of mechanisms underlying severe asthma inflammation has allowed the identifications of specific biomarkers guiding the clinician in the choice of patient specific drug. Among the suggested immunotherapeutic options, omalizumab (blocking IgE) remains the first choice for atopic "early ...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
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Source: Redox Biology - Category: Biology Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 16 August 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Paul Baldrick, James W. Hutchings, Matthew D. Heath, Murray A. SkinnerAbstractPQ Birch represents an allergen-specific immunotherapy for the treatment of birch pollinosis. It consists of native birch pollen extract chemically modified with glutaldehyde adsorbed to L-tyrosine in its microcrystalline form with addition of the adjuvant Monophosphoryl Lipid A (MPL®). A nonclinical safety testing strategy was designed based upon interpretation of current legislation and regulatory intelligence and comprised genotoxicity...
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Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Authors: Lyudmer M, Levy BJ, Holtzman AJ, Sankaranarayanan S, Tabeayo E, Gruson KI Abstract INTRODUCTION: Plain radiographs of the shoulder are routinely obtained for patients presenting with atraumatic shoulder pain, although the diagnostic utility of this imaging modality is unclear. Despite this, patients often prefer to obtain radiographs and may associate them with a more satisfactory visit. METHODS: New patients presenting with atraumatic shoulder pain were provided with information regarding the potential advantages and disadvantages of plain radiographs as part of their visit. Patients then decided whet...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
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Publication date: Available online 16 August 2019Source: NeuropsychologiaAuthor(s): Shiqing Song, Yixiao Zhang, Jiang Qiu, Xianjie Li, Ke Ma, ShuaiYu Chen, Hong ChenAbstractEating behaviors play an important role in individuals’ development, and restrained eaters have a higher risk of obesity in the future. In the present study, we used the Three-Factor Eating Questionnaire to measure restrained eating, uncontrolled eating, and emotional eating in 158 young, normal-weight, Chinese women. We developed a multiple linear regression model to identify significant structural brain changes associated with the above-mentione...
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Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
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