E3 ubiquitin ligases in B-cell malignancies.

E3 ubiquitin ligases in B-cell malignancies.
Cell Immunol. 2019 Feb 26;:
Authors: Choi J, Busino L
Abstract
Ubiquitylation is a post-translational modification (PTM) that controls various cellular signaling pathways. It is orchestrated by a three-step enzymatic cascade know as the ubiquitin proteasome system (UPS). E3 ligases dictate the specificity to the substrates, primarily leading to proteasome-dependent degradation. Deregulation of the UPS components by various mechanisms contributes to the pathogenesis of cancer. This review focuses on E3 ligase-substrates pairings that are implicated in B-cell malignancies. Understanding the molecular mechanism of specific E3 ubiquitin ligases will present potential opportunities for the development of targeted therapeutic approaches.
PMID: 30827673 [PubMed - as supplied by publisher]

Source: Cellular Immunology - February 25, 2019 Category: Allergy & Immunology Authors: Choi J, Busino L Tags: Cell Immunol Source Type: research