Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects [Neuroscience]

Genome damage and their defective repair have been etiologically linked to degenerating neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the specific mechanisms remain enigmatic. The majority of sporadic ALS patients feature abnormalities in the transactivation response DNA-binding protein of 43 kDa (TDP-43), whose nucleo-cytoplasmic mislocalization is...

http://www.pnas.org/content/116/10/4696.short?rss=1

Source: Proceedings of the National Academy of Sciences - March 4, 2019 Category: Science Authors: Joy Mitra, Erika N. Guerrero, Pavana M. Hegde, Nicole F. Liachko, Haibo Wang, Velmarini Vasquez, Junling Gao, Arvind Pandey, J. Paul Taylor, Brian C. Kraemer, Ping Wu, Istvan Boldogh, Ralph M. Garruto, Sankar Mitra, K. S. Rao, Muralidhar L. Hegde Tags: PNAS Plus Source Type: research