MicroRNA-214 promotes chronic kidney disease by disrupting mitochondrial oxidative phosphorylation

Mitochondria are critical in determining a cell ’s energy homeostasis and fate, and mitochondrial dysfunction has been implicated in the pathogenesis of chronic kidney disease (CKD). We sought to identify causative mitochondrial microRNAs. A microarray screen of kidney tissue from healthy mice identified 97 microRNAs that were enriched in the m itochondrial fraction. We focused on microRNA-214-3p (miR-214) because of a very high ratio of mitochondrial to cytoplasmic expression in the kidney compared to other organs.

Source: Kidney International - March 4, 2019 Category: Urology & Nephrology Authors: Mi Bai, Huimei Chen, Dan Ding, Ruihua Song, Jiajuan Lin, Yuanyuan Zhang, Yan Guo, Shuang Chen, Guixia Ding, Yue Zhang, Zhanjun Jia, Songming Huang, John Cijiang He, Li Yang, Aihua Zhang Tags: Basic Research Source Type: research