Mononuclear phagocytes orchestrate prolyl hydroxylase inhibition-mediated renoprotection in chronic tubulointerstitial nephritis

Prolyl hydroxylase domain enzyme inhibitors (PHDi) stabilize hypoxia-inducible factors (HIF), and are protective in models of acute ischemic and inflammatory kidney disease. Whether PHDi also confer protection in chronic inflammatory kidney disease models remains unknown. Here we investigated long-term effects of PHDi treatment in adenine-induced nephropathy as a model for chronic tubulointerstitial nephritis. After three weeks, renal dysfunction and tubulointerstitial damage, including proximal and distal tubular injury, tubular dilation and renal crystal deposition were significantly attenuated in PHDi-treated (the isoquinoline derivative ICA and Roxadustat) compared to vehicle-treated mice with adenine-induced nephropathy.

Source: Kidney International - March 4, 2019 Category: Urology & Nephrology Authors: Gunnar Schley, Bernd Klanke, Joanna Kalucka, Valentin Schatz, Christoph Daniel, Marleen Mayer, Margarete Goppelt-Struebe, Martin Herrmann, Margret Thorsteinsdottir, Runolfur Palsson, Angelika Beneke, D örthe M. Katschinski, Nicolai Burzlaff, Kai-Uwe Ecka Tags: Basic Research Source Type: research