A Man May Be Cleared of HIV for the Second Time in History. Here ’s What That Means

A man in London has become only the second person to achieve remission from HIV infection, researchers from the UK reported Tuesday. The therapy responsible has worked on only one other person who is considered to be “cured” of HIV: Timothy Ray Brown, who still does not show signs of the virus in his body after more than 10 years. Here’s what to know about the landmark case. How did it happen? In a letter published in the journal Nature, researchers led by Ravindra Gupta from the University of Cambridge London and Imperial College London and his colleagues say that they used a treatment similar to the one Brown received in 2007, but with a few changes meant to make the therapy easier and less intense for the patient. The London patient, who wishes to remain anonymous, was diagnosed with HIV in 2003 but did not begin anti-HIV drug therapy, which can keep the virus below detectable levels, until 2012. That year, he was also diagnosed with stage 4 Hodgkin’s lymphoma. To treat his cancer, he received chemotherapy and a bone marrow transplant in 2016; the chemotherapy killed the malignant and healthy cells in his immune system and blood, while the transplant gave him a fresh start with bone marrow cells from a healthy donor, which seeded a new population of cancer-free immune and blood cells. Brown had received two similar transplants to treat his leukemia; his donors were intentionally chosen because they not only matched him, but they also harbored genet...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized HIV/AIDS Source Type: news

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Transplant patients and people with lung diseases are among those who have been missed off the list.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
If you’re staying shut in your home, anxious about when you will finally be able to take a stroll outside or whether you or someone close to you will be infected by the novel coronavirus, you are not the only one. In the U.S. alone, half of the adults report high levels of anxiety due to the COVID-19, according to the  American Psychiatric Association. The ongoing pandemic is exerting the whole world both physically and mentally. One thing is sure to be asked by everyone: when will all this be over? Some think that things will never get back to normal. Acclaimed sci-fi writer Ted Chiang says that “we do...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine digital technology digital health tech digital health technologies coronavirus covid covid19 Source Type: blogs
The Fontan procedure is often the only definitive palliative surgical option for patients with a variety of complex CHD sharing in common, a single, dominant ventricle. In recent decades, imaging and therapeutic improvement have played a crucial role in those patients in whom many complications can hamper their life. After 50 years from the first procedure, heart transplantation remains the only definitive treatment for those with a failing Fontan circulation.
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Review Source Type: research
The aim of the study was to determine the association between pet ownership and cardiovascular risk factors and mortality. Electronic search was conducted through nine databases including PubMed for relevant publications reporting cardiovascular events and mortality among pet owners. Meta-analysis was used to pool the results. Of a total of 2818 reports screened, 26 studies were included in our systematic review and meta-analysis. Higher survival rate was observed in the pet owners group after pooling nonadjusted and adjusted hazard ratios for cardiovascular mortality at 0.73 [95% confidence interval (CI) 0.62–0.86] ...
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Research articles: Prevention Source Type: research
It is estimated that the three private clinic networks - Rutherford Health, Genesis Care and HCA UK - could treat an estimated 5,000 patients per month.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Publication date: Available online 6 April 2020Source: Journal of Molecular StructureAuthor(s): Saravanan Kandasamy, Prabhu Subramani, Selvi Subramani, John marshal Jayaraj, Gunasekaran Prasanth, Kannupal Srinivasan, Karthikeyan Muthusamy, Venkatachalam Rajakannan, Ravikumar Vilwanathan
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
m M Abstract The cytokine tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the large TNF superfamily that can trigger apoptosis in transformed or infected cells by binding and activating two receptors, TRAIL receptor 1 (TRAILR1) and TRAIL receptor 2 (TRAILR2). Compared to other death ligands of the same family, TRAIL induces apoptosis preferentially in malignant cells while sparing normal tissue and has therefore been extensively investigated for its suitability as an anti-cancer agent. Recently, it was noticed that TRAIL receptor signaling is also linked to endoplasmic reticulu...
Source: International Review of Cell and Molecular Biology - Category: Cytology Authors: Tags: Int Rev Cell Mol Biol Source Type: research
Mcl-1 as a "barrier" in cancer treatment: Can we target it now? Int Rev Cell Mol Biol. 2020;351:23-55 Authors: Pervushin NV, Senichkin VV, Zhivotovsky B, Kopeina GS Abstract During the last two decades, the study of Mcl-1, an anti-apoptotic member of the Bcl-2 family, attracted researchers due to its important role in cancer cell survival and tumor development. The significance of Mcl-1 protein in resistance to chemotherapeutics makes it an attractive target in cancer therapy. Here, we discuss the diverse possibilities for indirect Mcl-1 inhibition through its downregulation, for example, vi...
Source: International Review of Cell and Molecular Biology - Category: Cytology Authors: Tags: Int Rev Cell Mol Biol Source Type: research
Abstract Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), intracellular calcium (Ca2+) release channels, fulfill key functions in cell death and survival processes, whose dysregulation contributes to oncogenesis. This is essentially due to the presence of IP3Rs in microdomains of the endoplasmic reticulum (ER) in close proximity to the mitochondria. As such, IP3Rs enable efficient Ca2+ transfers from the ER to the mitochondria, thus regulating metabolism and cell fate. This review focuses on one of the three IP3R isoforms, the type 3 IP3R (IP3R3), which is linked to proapoptotic ER-mitochondrial Ca2+ transfer...
Source: International Review of Cell and Molecular Biology - Category: Cytology Authors: Tags: Int Rev Cell Mol Biol Source Type: research
Abstract Apoptosis is an important part of both health and disease and is often regulated by the BCL-2 family of proteins. These proteins are either pro- or anti-apoptotic, existing in a delicate balance during homeostasis. They are best known for their role in regulating the activation of caspases and the execution of a cell in response to a variety of stimuli. However, it is often forgotten that these BCL-2 family proteins also have important roles to play in cell maintenance that are not associated with apoptosis. These include roles in regulating processes such as cell cycle progression, mitochondrial function...
Source: International Review of Cell and Molecular Biology - Category: Cytology Authors: Tags: Int Rev Cell Mol Biol Source Type: research
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