Bone Marrow Transplant Renders Second Patient Free Of HIV

British doctors report the apparent eradication of HIV from a patient who was undergoing treatment for cancer. It's only the second time this has been accomplished, despite many attempts.(Image credit: SCIENCE SOURCE)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news

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This is the latest in a series of yearly posts in which I suggest areas of development for biotech startups I'd like to see actively developed as a part of the longevity industry in the near future. Today, this year, is a good time to be starting a company focused on the production of a novel therapeutic approach to intervening in the aging process. There is a great deal of funding for seed stage investment, and many compelling projects lacking champions, yet to be carried forward from academia into preclinical development. Numerous scientific and industry crossover conferences are now held every year, at which it is possi...
Source: Fight Aging! - Category: Research Authors: Tags: Investment Source Type: blogs
amura Mori Nakao Takami Heme oxygenase-1 (HO-1), an intracellular enzyme that catalyzes the degradation of heme into biliverdin, free iron, and carbon monoxide, exerts anti-inflammatory and cytoprotective effects against endothelial cell injury. The HO-1 promoter gene has one important single-nucleotide polymorphism (SNP) rs2071746 (-413A>T) that is functional, and the A allele has been reported to be associated with higher HO-1 expression levels than the T allele. We investigated the influence of the HO-1 rs2071746 SNP on the transplant outcomes in 593 patients with hematological malignancies undergoin...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Abstract Outcomes of treatment for malignant pediatric tumors including leukemia are improving by conventional multimodal treatment with strong chemotherapy, surgical resection, radiotherapy, and bone marrow transplantation. However, patients with advanced neuroblastoma, metastatic Ewing's sarcoma family of tumor (ESFT), and metastatic osteosarcoma continue to have an extremely poor prognosis. Therefore novel therapeutic strategies are urgently needed to improve their survival. Apoptotic cell death is a key mechanism for normal cellular homeostasis. Intact apoptotic mechanisms are pivotal for embryonic development...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Pigs with severe combined immunodeficiency (SCID) are an emerging biomedical animal model. Swine are anatomically and physiologically more similar to humans than mice, making them an invaluable tool for preclinical regenerative medicine and cancer research. One essential step in further developing this model is the immunological humanization of SCID pigs. In this work we have generated T− B− NK− SCID pigs through site directed CRISPR/Cas9 mutagenesis of IL2RG within a naturally occurring DCLRE1C (ARTEMIS)−/− genetic background. We confirmed ART−/−IL2RG−/Y pigs lacked T, B, an...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Title: Bone Marrow Transplants Less Risky NowCategory: Health NewsCreated: 1/29/2020 12:00:00 AMLast Editorial Review: 1/30/2020 12:00:00 AM
Source: MedicineNet Cancer General - Category: Cancer & Oncology Source Type: news
As palliative medicine expands within the scope of care for patients with cancer, the interface between hematologic malignancies and palliative care is increasing. These patients are underrepresented compared to their solid tumor counterparts regarding palliative care consultation. A growing body of literature supports earlier palliative care for patients with hematologic malignancies. From the impact of palliative care on bone marrow transplant patients' quality of life, utility of informatics in symptom assessment, and the role of transfusions in medical decision making regarding hospice, palliative medicine providers ar...
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Successful developments in disease control and management of early toxicity have seen outcome improvements in allogeneic bone marrow transplant (AlloBMT) resulting in increased numbers of patients transitioning to long term follow up (LTFU) care.LTFU care has traditionally been provided in quaternary centres by a dedicated LTFU team. A successful Victorian (Australia) Cancer Survivorship Program grant was utilised to pilot a shared survivorship model of care for eligible patients post AlloBMT. The Breaking Good shared survivorship care project built on the success in establishing a dedicated hospital based LTFU clinic by e...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 611 Source Type: research
The assessment of baseline physical function should be an important and integral component in the selection of patients to undergo a bone marrow transplant. This assessment can establish a baseline level of function that can be tracked as the person undergoes cancer treatment as well as during the survivorship period. It can also be used to identify physical impairments early that can subsequently be treated rehabilitative interventions to minimize activity limitations and participation restrictions.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 560 Source Type: research
Impaired physical function, fatigue and frailty are commonly seen in patients undergoing cancer treatment as well as in cancer survivors. These can have a significant adverse effect on the quality of life of the affected individuals.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 557 Source Type: research
Radiolabeled CD45 antibodies have demonstrated clinical promise as targeted conditioning agents prior to bone marrow transplant (BMT) as a better tolerated and potentially more effective alternative to chemotherapy and/or total body irradiation myeloablative conditioning regimens. CD45 is expressed on all immune cells, including hematopoietic stem cells and both precursor and mature lymphoid and myeloid cells, making it an ideal antigen for directing targeted radiation for conditioning. It is also highly expressed on most hematological cancers, offering the potential for a substantial anti-tumor effect.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 231 Source Type: research
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