Significance of BRCA1 expression in breast and ovarian cancer patients with brain metastasis - A multicentre study.

CONCLUSIONS: Patients with BC and OC and brain metastases have a frequent loss of BRCA1 expression. The role of ERα, PR, HER2, SDF1, CXCR4, AEG1, BRMS1 in metastatic process needs further studies.
PMID: 30822630 [PubMed - as supplied by publisher]

Source: Advances in Medical Sciences - February 25, 2019 Category: Biomedical Science Authors: Szarszewska M, Markowska A, Jach R, Marszałek A, Filas V, Bednarek W, Olejek A, Tomczak P, Sajdak S, Nowak-Markwitz E, Jaszczyńska-Nowinka K, Stanisławiak-Rudowicz J, Gryboś A, Chudecka-Głaz A, Gryboś M, Adamska K, Ramlau R, Markowska J, Knapp P Tags: Adv Med Sci Source Type: research