Deoxynivalenol-induced Oxidative Stress and Nrf2 Translocation in maternal Liver on Gestation Day 12.5 d and 18.5 d.

In conclusion, DON-induced ROS accumulation may cause maternal liver damage in the initial stages, but the related stimulation of Nrf2/HO-1 pathway improves the removal of ROS and decreases the level of oxidative stress thereby protecting the liver damage. Therefore, upregulating the Nrf2-dependent response is one of the potential methods that protects maternal liver from DON-induced oxidative damage. PMID: 30826469 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30826469?dopt=Abstract

Source: Toxicon - February 27, 2019 Category: Toxicology Authors: Yu M, Peng Z, Liao Y, Wang L, Li D, Qin C, Hu J, Wang Z, Cai M, Cai Q, Zhou F, Shi S, Yang W Tags: Toxicon Source Type: research