The Precuneus - A Witness for Excessive A β Gathering in Alzheimer's Disease Pathology.

CONCLUSIONS: The voxel-wise semiquantitative analysis shows that the precuneus is a region with higher vulnerability to Aβ depositions when compared to other cortical regions in both MCI-AD and ADD subjects. We think that the precuneus is a promising PET-based outcome measure for clinical trials of drugs targeting brain Aβ. We found a positive association between the overall Aβ-PET SUVr and the disease duration suggesting that the region-specific slow saturation of Aβ deposition continuously takes place as the disease progresses.
PMID: 30814473 [PubMed - as supplied by publisher]

Source: Neuro-Degenerative Diseases - February 26, 2019 Category: Neurology Authors: Aghakhanyan G, Vergallo A, Gennaro M, Mazzarri S, Guidoccio F, Radicchi C, Ceravolo R, Tognoni G, Bonuccelli U, Volterrani D Tags: Neurodegener Dis Source Type: research