Telomere elongation via alternative lengthening of telomeres (ALT) and telomerase activation in primary metastatic medulloblastoma of childhood

ConclusionsOur metastatic cases frequently activate ALT pathway, suggesting that it is a common process for senescence escape in primary metastatic medulloblastomas. Furthermore, the activation of mechanisms for telomere elongation is not restricted to certain molecular subgroups in this high-risk group of MDBs.

http://link.springer.com/10.1007/s11060-019-03127-w

Source: Journal of Neuro-Oncology - March 3, 2019 Category: Cancer & Oncology Source Type: research