TRIM29 facilitates the epithelial-to-mesenchymal transition and the progression of colorectal cancer via the activation of the Wnt/ β-catenin signaling pathway.

CONCLUSIONS: TRIM29 induces EMT through activating the Wnt/β-catenin signaling pathway via up-regulating CD44 expression, thus promoting invasion and metastasis of CRC. PMID: 30813948 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30813948?dopt=Abstract

Source: Clinical Colorectal Cancer - February 26, 2019 Category: Cancer & Oncology Authors: Sun J, Zhang T, Cheng M, Hong L, Zhang C, Xie M, Sun P, Fan R, Wang Z, Wang L, Zhong J Tags: J Exp Clin Cancer Res Source Type: research