Viruses, Vol. 11, Pages 212: Efficacy of an Adjuvanted Middle East Respiratory Syndrome Coronavirus Spike Protein Vaccine in Dromedary Camels and Alpacas
Viruses, Vol. 11, Pages 212: Efficacy of an Adjuvanted Middle East Respiratory Syndrome Coronavirus Spike Protein Vaccine in Dromedary Camels and Alpacas
Viruses doi: 10.3390/v11030212
Authors:
Danielle R. Adney
Lingshu Wang
Neeltje van Doremalen
Wei Shi
Yi Zhang
Wing-Pui Kong
Megan R. Miller
Trenton Bushmaker
Dana Scott
Emmie de Wit
Kayvon Modjarrad
Nikolai Petrovsky
Barney S. Graham
Richard A. Bowen
Vincent J. Munster
MERS-CoV is present in dromedary camels throughout the Middle East and Africa. Dromedary camels are the primary zoonotic reservoir for human infections. Interruption of the zoonotic transmission chain from camels to humans, therefore, may be an effective strategy to control the ongoing MERS-CoV outbreak. Here we show that vaccination with an adjuvanted MERS-CoV Spike protein subunit vaccine confers complete protection from MERS-CoV disease in alpaca and results in reduced and delayed viral shedding in the upper airways of dromedary camels. Protection in alpaca correlates with high serum neutralizing antibody titers. Lower titers of serum neutralizing antibodies correlate with delayed and significantly reduced shedding in the nasal turbinates of dromedary camels. Together, these data indicate that induction of robust neutralizing humoral immune responses by vaccination of naïve animals reduces shedding that potentially could diminish the risk of zoonotic transmission.
Source: Viruses - Category: Virology Authors: Danielle R. Adney Lingshu Wang Neeltje van Doremalen Wei Shi Yi Zhang Wing-Pui Kong Megan R. Miller Trenton Bushmaker Dana Scott Emmie de Wit Kayvon Modjarrad Nikolai Petrovsky Barney S. Graham Richard A. Bowen Vincent J. Munster Tags: Article Source Type: research
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