Outcome of cranial surgery in Nigerian patients with hemoglobinopathies: A retrospective study.

Conclusion: Neurosurgery is possible and safe in patients with hemoglobin disorders. Adequate preoperative preparation, proper anesthetic techniques, meticulous surgery, and excellent postoperative care can help optimize outcome of surgical intervention in this patient population. PMID: 30815324 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

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Authors: Ferreira LP, Pinheiro CF, Fernandes NA, Ferreira CN PMID: 31730304 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Conclusion: The positive and negative points of the image-based cell models and computergenerated cell models some scientific advices are presented in this work. Generally, the imagebased cell models could offer analytical facts for each state, but they are expensive and timeconsuming; besides, their performance is heavily influenced by deformation techniques. The computer-generated cell model, on the other hand, provides a higher cost of production and simplicity, but its main contribution is the overall performance and accuracy.
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
AbstractAtypical teratoid/rhabdoid tumor (ATRT) is a highly malignant brain tumor predominantly occurring in infants. Mutations of theSMARCB1 gene are the characteristic genetic lesion. SMARCB1-mutant tumors in adolescents and adults are rare and may show uncommon histopathological and clinical features. Here we report seven SMARCB1-deficient intracranial tumors sharing distinct clinical, histopathological and molecular features. Median age of the four females and three males was 40  years (range 15–61 years). All tumors were located in the pineal region. Histopathologically, these tumors displayed spindled...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
In this study, we investigated the effects of AMPA receptor antagonist perampanel in rat C6 glioma model. In first pilot experiments, perampanel reduced glucose uptake but had no impact of extracellular glutamate level in vitro. To analyze the effects of perampanel in vivo, we injected C6 cells orthotopically into the neocortex of Wistar rats in order to establish a model of glioma-associated epilepsy. Spontaneous recurrent discharges in brain slices were abolished upon perfusion with the AMPA receptor blocker perampanel, supporting the major role of glutamatergic excitation. With respect to the tumor progression, no effec...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: December 2019Source: Journal of Clinical Neuroscience, Volume 70Author(s): Ebrahim Najafzadeh, Hossein Ghadiri, Maysam Alimohamadi, Parastoo Farnia, Mohammad Mehrmohammadi, Alireza AhmadianAbstractAccurate margin delineation and safe maximal resection of glioma is one of the most challenging problems of neurosurgery, due to its close resemblance to normal brain parenchyma. However, different intraoperative visualization methods have been used for real-time intraoperative investigation of the borders of the resection cavity, each having advantages and limitations. This preliminary study was designed to sim...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 13 November 2019Source: Journal of Neuroscience MethodsAuthor(s): Brittanie Partridge, John H. RossmeislAbstractClinical translation of novel therapeutics that improve the survival and quality of life of patients with neurological disease remains a challenge, with many investigational drug and device candidates failing in advanced stage clinical trials. Naturally occurring inherited and acquired neurological diseases, such as epilepsy, inborn errors of metabolism, brain tumors, spinal cord injury, and stroke occur frequently in companion animals, and many of these share epidemiologic, pat...
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
In this study, taking advantage of the currently popular computational methods for estimating the infiltration of tumor-associated normal cells in tumor samples and using weighted gene co-expression network analysis, we screened the co-expressed gene modules associated with the TME and further identified the prognostic hub genes in these modules. Furthermore, eight prognostic hub genes (ARHGDIB, CLIC1, OAS3, PDIA4, PARP9, STAT1, TAP2, and TAGLN2) were selected to construct a prognostic risk score model using the least absolute shrinkage and selection operator method. Univariate and multivariate Cox regression analysis demo...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
ConclusionsExisting literature suggests that the application of radiation chronotherapy may reduce negative symptom outcome within highly proliferative tissues. Further examination of radiation chronotherapy in well-designed prospective trials and studies in brain tumor patients are merited.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsOur findings suggest that histone deacetylase inhibitors are potent therapeutic agents against medulloblastoma.
Source: Experimental Hematology and Oncology - Category: Cancer & Oncology Source Type: research
This study aimed to investigate the effect of radiation on tumor growth and the GSC microenvironment in a mouse model of glioma. To evaluate the growth-inhibitory effects of ionizing radiation on GSCs, tumor volume was measured via anatomical magnetic resonance imaging (MRI) after the intracranial injection of 1 × 104 human patient-derived GSCs (83NS cells), which exhibit marked radioresistance. When a tumor mass of ~5 mm3 was detected in each animal, 10 Gy of cranial irradiation was administered. Tumor progression was observed in the orthotopic xenografted GSC tumor (primary tumor) from a detectable tumor mass (5 mm...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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