TRIM69 inhibits cataractogenesis by negatively regulating p53

In conclusion, we provide the first demonstration that Foxo3a is a potential transcription factor for TRIM69, and TRIM69 induces p53 ubiquitination. These results suggest that the Foxo3a/TRIM69/p53 regulatory network may be involved in cataract formation.Graphical abstract

Source: Redox Biology - March 4, 2019 Category: Biology Source Type: research