Direct and bystander effects in human blood lymphocytes exposed to 241Am alpha particles and the relative biological effectiveness using chromosomal aberration and micronucleus assay.

CONCLUSION: The magnitude of low fluence α-particle induced RIBE is higher than in low LET (linear energy transfer) radiation. The RBE also varies depending upon the endpoints used and adds up to targeted effects. Since the endpoint of CA is considered as important and early marker of risk prediction, the RIBE and RBE using CA as a marker are relevant for radiation protection purposes.
PMID: 30821557 [PubMed - as supplied by publisher]

Source: International Journal of Radiation Biology - March 4, 2019 Category: Radiology Tags: Int J Radiat Biol Source Type: research