Chemotherapy workers face risks, reduced with safe handling

Analysis finds moderate level of evidence that workplace exposure is associated with increased risk of miscarriage and genetic damage (read more)
Source: Environmental Factor - NIEHS Newsletter - Category: Environmental Health Source Type: news

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A majority of miscarriages have been thought to be caused by fertile ovum abnormalities; however, our findings suggest that a small uterus can also potentially cause miscarriage. There are no reports on the association between a small uterus and miscarriage. A woman in her late 20s, whose medical history revealed childhood acute lymphocytic leukemia, which progressed to remission after chemotherapy, radiotherapy, and bone marrow transplantation. Ultrasound revealed no ovarian follicles in either of the ovaries and small uterus (length, 32 mm) In cycle 15, after ovum collection, frozen embryos with Veeck ’s classifica...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions MDSC are major players in the immunosuppressive scenario in cancer, thanks to their phenotype heterogeneity and critical interaction with several innate immune cells, thus representing a crucial target in oncology. Here we reviewed the interactions of MDSCs with NK cells. The contribution of key cytokines, chemokines and mediators active in this process have been discussed. We also described the contribution of MDSC on angiogenesis directly or indirectly through interactions with NK and immunosuppressive activities. A parallel of the cancer associated to the decidual counterpart of these cells is discussed, a...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The objective of this study was to report reproductive outcomes following fertility-sparing treatment for a gynaecological cancer.MethodsElectronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a gynecological malignancy.ResultsIn total, 77 studies were included which reported on reproductive outcomes after treatment for cervical cancer, endometrial cancer, gestational trophoblastic disease, and ovarian cancer. The main treatments included vaginal or abdominal radical trachelectomy, progestin therapy, salpingo-oophorectomy, and chemotherapy. The mean age at diagnosis...
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
Background.Infertility is common after HCT predominantly as a result of the chemoradiotherapy used in conditioning. Patients are increasingly encouraged to store gametes, tissue or embryos before transplant for use after their potentially sterilising treatment. Furthermore, some patients do retain or recover fertility and conceive naturally.Methods:We sent questionnaires to 602 EBMT centers requesting retrospective details of number of pregnancies following either allogeneic or autologous HCT, use of artificial reproductive techniques (ART) and pregnancy outcome for all patients treated between 1995-2015.Results:47 centers...
Source: Blood - Category: Hematology Authors: Tags: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Poster I Source Type: research
Conclusions Surgery, including hysterectomy and resection of metastatic disease, is an important component in the treatment of women with ETT. Adjuvant chemotherapy with a platinum/etoposide-containing regimen should be used in women with metastatic disease. All 5 women with ETT in this series were cured using this approach, including the 4 who had metastatic disease.
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: Gestational Trophoblastic Neoplasia Source Type: research
“Well, it’s the good kind of cancer. You will be better soon.” Those are the words Elizabeth Gillette heard from some people when she was diagnosed with Hodgkin’s Lymphoma at 21 years old. She would need several rounds of chemotherapy followed by radiation treatment. She was terrified — and shocked to hear anyone refer to her cancer as good. These “responses effectively closed me off to having any further conversation with them because I knew they didn’t understand how scared I was feeling,” said Gillette, LCSW, now an attachment-focused therapist, who specializes in working...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Family Friends General Health-related Mental Health and Wellness Relationships Self-Help Bereavement Coping Failure grief grieving loss Tragedy Source Type: blogs
Conclusion: Our study suggests that gonadotropin releasing hormone-a administered during chemotherapy can prevent premature ovarian failure in patients treated without HSCT and that it is not enough to preserve the ovarian function during HSCT. Hence, a prospective randomized trial with a larger population would be recommended.
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Original Articles Source Type: research
Conclusions This strategy achieves live births in four of 10 eCC women who desire fertility, whereas their risk of miscarriage is low. Three of 10 live births will be premature.
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research
Conclusion: Epithelioid trophoblastic tumor and its hybrids are difficult to diagnose. They may be diagnosed as moderately differentiated squamous cell carcinoma especially in low resource settings where cervical squamous cell carcinoma is relatively more common. A high index of suspicion, a serum β HCG test and close collaboration between clinicians and pathologists can help make the diagnosis. Funding: None. PMID: 29622835 [PubMed - in process]
Source: Ghana Medical Journal - Category: African Health Tags: Ghana Med J Source Type: research
AbstractAdult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically. By contrast, radiation is detrimental to both the ovaries and the uterus, thereby causing a gr...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Review, Gynecologic Oncology Source Type: research
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