Ex Vivo Drug Sensitivity Testing and Mutation Profiling
Conditions: Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Large Cell Lymphoma; Refractory Childhood Acute Lymphoblastic Leukemia; Refractory Childhood Hodgkin Lymphoma; Refractory Childhood Malignant Ger m Cell Neoplasm; Recurrent Childhood Brain Tumor; Recurrent Childhood Brainstem Glioma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Childhood Ependymoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childh ood Gliosarcoma; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive Intervention: Sponsors: Florida International University; Nicklaus Children's Hospital f/k/a Miami Children's Hospital Recruiting
Publication date: Available online 15 June 2019Source: Pathology - Research and PracticeAuthor(s): Xi Chen, Zhibo Guo, Shengjin Fan, Lili Sun, Huibo Li, Jin Zhou, Yinghua LiAbstractT-cell acute lymphoblastic leukemia (T-ALL) has a relatively improved remission rate, but the poor outcomes are primarily due to resistance and relapse. Moreover, organs infiltration trends to occur during remission. Rapamycin was applied to treat malignancies for decades. In this investigation, we aimed to explore the molecular mechanisms and pathway changes during the T-ALL therapeutic process. T-ALL cell line Molt-4 cells were treated with ra...
We describe the experimental setup and the tools for cell tracking and data analysis. PMID: 31197771 [PubMed - in process]
Authors: Pileri A, Gunnella S, Grandi V, Maio V, Santucci M, Pimpinelli N, Lymphoma Italian Foundation (Fondazione Italiana Linfomi, FIL) - Cutaneous Lymphoma Task Force (Commissione Linfomi Cutanei) PMID: 31195783 [PubMed - as supplied by publisher]