Gadolinium breast MRI screening OK for healthy women

VIENNA - Healthy women at high risk for developing breast cancer should have...Read more on AuntMinnie.comRelated Reading: Video from ECR 2019: Alexander Radbruch on gadolinium debate Gadolinium in gliomas, adjacent tissue raises questions German study may offer new way to detect gadolinium Patients report long-term gadolinium presence in urine Gadolinium accumulation might be more widespread than thought
Source: Headlines - Category: Radiology Source Type: news

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ConclusionsThese results suggest that Triptolide may be used to reverse CD4+ T cell inhibition caused by glioma cells and is an alternative candidate for targeting PD-L1, one of the checkpoint inhibitors for the treatment of glioma.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
1399Introduction: Somatostatin receptor (SSTR) targeting peptide receptor radiotherapy (PRRT) has been successfully introduced to the clinic, treating well-differentiated neuroendocrine tumor (NET) patients. Although SSTR is a promising theranostics target, the indication is limited to typical NET. Thus, broadening the scope of current clinical application is necessary. Here, we analyzed the clinical and genetic portraits related to SSTR expression across 9962 subjects representing 32 cancers. Methods: SSTR expression levels were assessed by RNA-seq data of the Cancer Genome Atlas. As the major target of PRRT is SSTR subty...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Oncology, Basic and Translational (Basic Science) Posters Source Type: research
Conclusions: 18F-Fluoroglutamine PET appears sensitive for diagnosis of early/late progression of brain tumor progression post-treatment.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Brain Imaging Targets Source Type: research
AbstractSphingosine-1-phosphate (S1P) can regulate several physiological and pathological processes. S1P signaling via its cell surface receptor S1PR1 has been  shown to enhance tumorigenesis and stimulate growth, expansion, angiogenesis, metastasis, and survival of cancer cells. S1PR1-mediated tumorigenesis is supported and amplified by activation of downstream effectors including STAT3, interleukin-6, and NF-κB networks. S1PR1 signaling can also trigge r various other signaling pathways involved in carcinogenesis including activation of PI3K/AKT, MAPK/ERK1/2, Rac, and PKC/Ca, as well as suppression of cyc...
Source: Molecular Diagnosis and Therapy - Category: Molecular Biology Source Type: research
Conclusions: In this study, 68Ga-NOTA-NFB has been confirmed can observe majority of breast cancer lesions as 18F-FDG. And it was a new tracer for no-invasive determination of CXCR4 expression, as well as may be used into selecting of patients those suit for CXCR4 therapy. [Key words]breast cancer; Positron-emission tomography; Tomography, X-ray computed; Gallium radioisotopes; chemokine receptor 4
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Breast Cancer Posters Source Type: research
In this study, we aimed to explore its expression and clinical significance in glioma. PATIENTS AND METHODS: Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) assays were performed to detect the expression levels of MAGI2-AS3 in fresh glioma and matched adjacent normal brain tissue specimens, which were collected from 178 patients. Then the association between MAGI2-AS3 expression and clinical-pathological parameters were further evaluated using the Chi-square test. The overall survival (OS) was analyzed by the log-rank test, and the survival curves were plotted according to Kaplan-Meier. Univariate and multiv...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Antonio Lucena-Cacace1, Masayuki Umeda1, Lola E. Navas2,3 and Amancio Carnero2,3* 1Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan 2CIBERONC, ISCIII, Madrid, Spain 3Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío (HUVR), CSIC, Universidad de Sevilla, Sevilla, Spain Glioma Cancer Stem-Like Cells (GSCs) are a small subset of CD133+ cells with self-renewal properties and capable of initiating new tumors contributing to Glioma progression, maintenance, hierarchy, and complexity. GSCs are highly res...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Michal Yalon1†, Amos Toren1,2†, Dina Jabarin2, Edna Fadida3, Shlomi Constantini3 and Ruty Mehrian-Shai1* 1Pediatric Hemato-Oncology, Edmond and Lilly Safra Children's Hospital and Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel 2The Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel 3Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv-Sourasky Medical Center, Tel Aviv, Israel Pediatric brain tumors are the most common solid tumor type and the leading cause of cancer-related death in children. The immune system plays an important r...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions Several model systems are now available to characterize the MSC-tumour interplay in the TME. These offer early promise in establishing robust preclinical platforms for the identification of crucial molecular pathways and for the assessment of clinical efficacy of novel drugs to inhibit cancer development and progression. However, selection of the right model for a given study should be shaped on the purpose, and should also consider fixed biological, biochemical, and biophysical parameters according to the specific tumour type. Finally, in order to get reliable and useful results to be translated to the clinic...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: This meta-analysis demonstrated that CD44 overexpression might be an unfavorable prognostic factor for CRC patients and could be used to predict poor differentiation, lymph node metastasis and distant metastasis. Introduction Although therapies for colorectal cancer (CRC) has improved in recent years, colorectal cancer is still the third most common cause of cancer related death worldwide (1). Metastasis are observed in 25% of patients at initial diagnosis and approximately 50% of patients will develop metastasis (2). Presently, the outcome prediction and the therapy schedule determination of CRC patie...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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