PET, fMRI shed light on alcohol's effects on brain

Data from a combination of FDG-PET and functional MRI (fMRI) scans revealed...Read more on AuntMinnie.comRelated Reading: DTI-MRI shows drinking affects young men and women differently fMRI shows what makes an angry drunk PET, fMRI find beer reflex in brain SNMMI: PET/CT uncovers adaptations in alcoholic brain PET exposes shift in brain function among young alcohol abusers
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Conclusion: There may be an association between schizophrenia and HNPP. In observational studies, the deletion of interest (chromosome 17p12) was nearly 10 times more common in schizophreniform patients than in controls. This potential association could be pathophysiologically explained by the role of PMP22, which is mainly expressed in the peripheral nervous system. However, PMP22 mRNA and protein can also be found in the brain. PMP22 seems to play an important role in regulating cell growth and myelination, functions that are disturbed in schizophrenia. Such a connection obviously cannot be clarified on the basis of one ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
We examined the expression of TRPV1 in peripheral tissue and DRG neurons of CPIP model rats and we studied whether CPIP model could induce peripheral sensitization of TRPV1 channel and enhance DRG neuron excitability. Then we examined the therapeutic effects of locally applied TRPV1 specific antagonist AMG9810 on pain responses of CPIP model rats. Lastly, we explored the effects of AMG9810 on DRG neuron hyperexcitability and spinal glial activation induced by CPIP. Our results demonstrate that TRPV1 plays an important role in mediating the behavioral hypersensitivity of CPIP model rats via promoting peripheral nociceptor a...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
By SAURABH JHA Of my time arguing with doctors, 30 % is spent convincing British doctors that their American counterparts aren’t idiots, 30 % convincing American doctors that British doctors aren’t idiots, and 40 % convincing both that I’m not an idiot. A British doctor once earnestly asked whether American physicians carry credit card reading machines inside their white coats. Myths about the NHS can be equally comical. British doctors don’t prostate every morning in deference to the NHS, like the citizens of Oceania sang to Big Brother in Orwell’s dystopia. Nor, in their daily rounds, do the...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: OP-ED Uncategorized AlfieEvans Source Type: blogs
It may seem like stress is an external force — something that happens to you, such as a rude driver, a work deadline, or the illness of a loved one. As a result, it may seem like there’s really nothing you can do about your stress, but this simply isn’t the case. You may not be able to shape the world so that nothing stressful ever happens to you again, but you can change the way you respond to stress, and that can make all the difference in how you feel.   The most fundamental thing to understand about stress is that it isn’t a one-time event with one cause and one reaction. It’s actuall...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Habits Happiness LifeHelper Motivation and Inspiration Self-Help Stress Coping Skills Cortisol fight or flight homeostatis neuroception Reactivity Self Medication Stress Hormone stress reduction Stress Response Sympathetic Source Type: blogs
In conclusion, in the Framingham Heart Study population, in the last 30 years, disease duration in persons with dementia has decreased. However, age-adjusted mortality risk has slightly decreased after 1977-1983. Consequences of such trends on dementia prevalence should be investigated. Recent Research on the Benefits of Exercise in Later Life https://www.fightaging.org/archives/2018/04/recent-research-on-the-benefits-of-exercise-in-later-life/ A sizable body of work points to the ability of older individuals to continue to obtain benefits through regular physical activity, and particularly in the case ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Written by Pendell Meyers, with edits by Steve SmithThanks to my attending Nic Thompson who superbly led this resuscitationWe received a call that a middle aged male in cardiac arrest was 5 minutes out. He was estimated to be in his 50s, with no known PMHx. He arrived with chest compressions ongoing, intubated, and being bagged. EMS report was that the patient had unknown down time with unwitnessed arrest, found initially in VFib arrest, defibrillated x1 followed by PEA arrest alternating with asystolic arrest during transport.He arrived in PEA arrest with a slow and wide cardiac waveform during initial rhythm check, with ...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
When a doctor in your hospital system kills himself, the entire medical staff receives a mass email informing everyone of “Dr. So-and-So’s sudden unexpected death”. Thoughts and prayers for his family and loved ones. Perhaps a link to your Employee Assistance Program is provided, for those who may need counseling or grief assistance.  This is followed later that day with another email detailing the schedule for the final arrangements. Calling hours. Funeral. Directions to the church.Not everyone will have known the physician. So most scan the email and then go about thei...
Source: Buckeye Surgeon - Category: Surgery Authors: Source Type: blogs
While a biopsychosocial ‘model’ (or sociopsychobiological framework) has been widely adopted when attempting to understand pain, many critics argue that it just doesn’t give clinicians a clear way to integrate or prioritise clinical information and generate treatments. The ‘model’ itself has been challenged from many angles – it’s too complex, too simplistic, relies on Bertalanffy’s “general systems theory” which has itself been challenged, it’s too “fuzzy”, and of course there are many who think that psychological and sociocultural aspects of hu...
Source: HealthSkills Weblog - Category: Anesthesiology Authors: Tags: Clinical reasoning Coping strategies Professional topics Research Science in practice biopsychosocial treatment Source Type: blogs
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