Getting Excited About Paroxysms: Why Treating Sympathetic Hyperarousal After Traumatic Brain Injury May Be More Important Than We Appreciated*

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Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Editorials Source Type: research

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Publication date: Available online 19 March 2019Source: Physiology &BehaviorAuthor(s): Gaia Fragiotta, Francesco Pierelli, Gianluca Coppola, Carmela Conte, Armando Perrotta, Mariano SerraoAbstractTo explore the role of strong negative emotions in spinal nociception, we evaluated the effect of fear-relevant videos of small animals on the nociceptive withdrawal reflex (NWR) and reflex-related pain perception in healthy subjects with a specific phobia of small animals. Twenty healthy subjects with a specific phobia of small animals diagnosed according to DSM-V criteria were included in this study. The NWR was evoked in th...
Source: Physiology and Behavior - Category: Physiology Source Type: research
Publication date: Available online 19 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Elaine Ku, Benjamin J. Lee, Jenny Wei, Matthew R. WeirHypertension and chronic kidney disease (CKD) are closely interlinked pathophysiologic states, such that sustained hypertension can lead to worsening kidney function and progressive decline in kidney function can conversely lead to worsening blood pressure (BP) control. The pathophysiology of hypertension in CKD is complex and is a sequela of multiple factors, including reduced nephron mass, increased sodium retention and extracellular volume expansion, sympathetic nerv...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
PURPOSE: Studies have shown that children with muscular dystrophy are at increased risk for falls, however there is insufficient information about what predicts the first and subsequent events. The purpose of this study was to describe the experience of in...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
In conclusion, BLU-5937 was selected as a drug candidate for the treatment of chronic cough due to its high potency and selectivity for P2X3 homotrimeric receptors, strong anti-tussive effects, excellent tolerability and predicted pharmacokinetic properties in humans.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
Publication date: Available online 19 March 2019Source: SeizureAuthor(s): Ilaria Lagorio, Federico Zara, Salvatore Striano, Pasquale StrianoAbstractFamilial adult myoclonic epilepsy (FAME), also described with different acronyms (ADCME, BAFME, FEME, FCTE and others), is a high-penetrant autosomal dominant condition featuring cortical hand tremors, myoclonic jerks, and occasional/rare convulsive seizures. Prevalence is unknown since this condition is often under-recognized, but it is estimated to be less than 1/35,000. The disease usually starts in the second decade of life and has been genetically associated with at least ...
Source: Seizure - Category: Neurology Source Type: research
Publication date: Available online 19 March 2019Source: Anaesthesia &Intensive Care MedicineAuthor(s): Carla Gould, Jon HopperAbstractMaintaining an equilibrium between oxygen supply and demand is a principal function of the cardiovascular system. In times of altered metabolic demand mechanisms exist to maintain the balance between supply and demand. Exercise, haemorrhage and pregnancy all lead to changes in oxygen demand and subsequently modification of cardiac output. During isotonic exercise, metabolic demands of muscle are greatly increased. Sympathetic stimulation and inhibition of the parasympathetic system lead ...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Condition:   Duchenne Muscular Dystrophy Intervention:   Sponsor:   Genethon Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: Wheelchair use and heart conditions associated with reduced risk of falls likely reflects decreased mobility. Clinicians should help families identify factors associated with falls among those who remain ambulatory. PMID: 30883368 [PubMed - as supplied by publisher]
Source: Journal of Pediatric Rehabilitation Medicine - Category: Rehabilitation Tags: J Pediatr Rehabil Med Source Type: research
Abstract BACKGROUND AND PURPOSE: Eye movements may be adversely affected after mild traumatic brain injury (mTBI) and should be examined. The purpose of this topical review is to provide the clinician with the most up-to-date knowledge related to eye movement abnormalities, screening measures, and evidence related to exercise interventions that are designed to enhance outcomes in persons after mTBI. SUMMARY OF KEY POINTS: Presence of eye misalignment such as tropias or phoria or symptoms with head/eye movements such as vestibulo-ocular reflex (VOR) × 1, saccades, or smooth pursuits may slow the person's...
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: J Neurol Phys Ther Source Type: research
Abstract BACKGROUND AND PURPOSE: Unilateral incremental vestibulo-ocular reflex (VOR) adaptation (IVA) increases the VOR gain (= eye/head velocity) for head rotations to one side by ∼10%. Prior IVA studies involved setting the initial VOR training gain demand at the subject's starting value (= 1 in a healthy subject), with the gain preset to increment by 0.1 every 90 seconds over 15 minutes, defined as Static IVA. We determined whether a dynamically calculated gain demand (= "actual gain" + 0.1) would result in greater adaptation, defined as Dynamic IVA. METHODS: Using a hybrid video-oculography...
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: J Neurol Phys Ther Source Type: research
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